Nicotine Induces Resistance to Chemotherapy by Modulating Mitochondrial Signaling in Lung Cancer

Continued smoking causes tumor progression and resistance to therapy in lung cancer. Carcinogens possess the ability to block apoptosis, and thus may induce development of cancers and resistance to therapy. Tobacco carcinogens have been studied widely; however, little is known about the agents that...

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Veröffentlicht in:	American journal of respiratory cell and molecular biology 2009-02, Vol.40 (2), p.135-146
Hauptverfasser:	Zhang, Jingmei, Kamdar, Opal, Le, Wei, Rosen, Glenn D, Upadhyay, Daya
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Combined Chemotherapy Protocols - pharmacology Antineoplastic Combined Chemotherapy Protocols - therapeutic use Apoptosis - drug effects bcl-2-Associated X Protein - metabolism Carcinogens - toxicity Caspase 9 - metabolism Cell Line, Tumor Cisplatin - pharmacology Cisplatin - therapeutic use Drug Resistance, Neoplasm - drug effects Etoposide - pharmacology Etoposide - therapeutic use Humans Lung cancer Lung Neoplasms - drug therapy Lung Neoplasms - metabolism MAP Kinase Kinase 1 - antagonists & inhibitors MAP Kinase Kinase 1 - metabolism MAP Kinase Kinase 2 - antagonists & inhibitors MAP Kinase Kinase 2 - metabolism MAP Kinase Signaling System - drug effects Membrane Potential, Mitochondrial - drug effects Mitochondria - metabolism Mitochondria - pathology Nicotine - adverse effects Nicotinic Agonists - adverse effects Protein Transport - drug effects Proto-Oncogene Proteins c-akt - metabolism RNA, Small Interfering - pharmacology Smoking - adverse effects
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