Hydrolytic Degradation of Poly(ethylene oxide)-block-Polycaprolactone Worm Micelles
Spherical micelles and nanoparticles made with degradable polymers have been of great interest for therapeutic application, but degradation-induced changes in a spherical morphology can be subtle and mechanism/kinetics appears poorly understood. Here, we report the first preparation of giant and fle...
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| Veröffentlicht in: | Journal of the American Chemical Society 2005-09, Vol.127 (37), p.12780-12781 |
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| container_title | Journal of the American Chemical Society |
| container_volume | 127 |
| creator | Geng, Yan Discher, Dennis E |
| description | Spherical micelles and nanoparticles made with degradable polymers have been of great interest for therapeutic application, but degradation-induced changes in a spherical morphology can be subtle and mechanism/kinetics appears poorly understood. Here, we report the first preparation of giant and flexible worm micelles self-assembled from degradable copolymer poly(ethylene oxide)-block-polycaprolactone. Such worm micelles spontaneously shorten to generate spherical micelles, triggered by polycaprolactone hydrolysis, with distinct mechanism and kinetics from that which occurs in bulk material. |
| doi_str_mv | 10.1021/ja053902e |
| format | Article |
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Am. Chem. Soc</addtitle><description>Spherical micelles and nanoparticles made with degradable polymers have been of great interest for therapeutic application, but degradation-induced changes in a spherical morphology can be subtle and mechanism/kinetics appears poorly understood. Here, we report the first preparation of giant and flexible worm micelles self-assembled from degradable copolymer poly(ethylene oxide)-block-polycaprolactone. Such worm micelles spontaneously shorten to generate spherical micelles, triggered by polycaprolactone hydrolysis, with distinct mechanism and kinetics from that which occurs in bulk material.</description><subject>Applied sciences</subject><subject>Exact sciences and technology</subject><subject>Hydrolysis</subject><subject>Micelles</subject><subject>Organic polymers</subject><subject>Physicochemistry of polymers</subject><subject>Polyesters - chemistry</subject><subject>Polyethylene Glycols - chemistry</subject><subject>Properties and characterization</subject><subject>Solution and gel properties</subject><subject>Temperature</subject><subject>Time Factors</subject><issn>0002-7863</issn><issn>1520-5126</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkU9vEzEQxS0EomnhwBdAewHRw4L_rO31BQkVaKoWUdSVkLhYU-9s63SzDvamar59HRIlIHGy7PfzmzczhLxi9D2jnH2YAZXCUI5PyIRJTkvJuHpKJpRSXupaiQNymNIsXytes-fkgCkmDZfVhFxNV20M_Wr0rviMNxFaGH0YitAVl_n5HY63qx4HLMKDb_G4vO6DuyvXkoNF_ghuDFn9GeK8-OYd9j2mF-RZB33Cl9vziDRfvzQn0_Li--nZyaeLEqTQY8lpV0tklDrXyqqlXHRGoFEV46bttDOojVLIjOKoHW21FAhVLZnroJJaHJGPG9vF8nqOrcNhjNDbRfRziCsbwNt_lcHf2ptwb7kS3PwxeLs1iOH3EtNo5z6tW4ABwzJZVUvNGecZPN6ALoaUIna7Ioza9QbsbgOZff13qj25HXkG3mwBSA76LsLgfNpzmjHBVJ25csP5NOLDTod4Z5UWWtrm8sqaujmf_qKN_bH3BZfsLCzjkGf_n4CPc5OqOg</recordid><startdate>20050921</startdate><enddate>20050921</enddate><creator>Geng, Yan</creator><creator>Discher, Dennis E</creator><general>American Chemical Society</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20050921</creationdate><title>Hydrolytic Degradation of Poly(ethylene oxide)-block-Polycaprolactone Worm Micelles</title><author>Geng, Yan ; Discher, Dennis E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a537t-20f85e100ccd54d023f93e964129df7c9e7966e1962e7c0d753ea4851cfa4573</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Applied sciences</topic><topic>Exact sciences and technology</topic><topic>Hydrolysis</topic><topic>Micelles</topic><topic>Organic polymers</topic><topic>Physicochemistry of polymers</topic><topic>Polyesters - chemistry</topic><topic>Polyethylene Glycols - chemistry</topic><topic>Properties and characterization</topic><topic>Solution and gel properties</topic><topic>Temperature</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Geng, Yan</creatorcontrib><creatorcontrib>Discher, Dennis E</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of the American Chemical Society</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Geng, Yan</au><au>Discher, Dennis E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hydrolytic Degradation of Poly(ethylene oxide)-block-Polycaprolactone Worm Micelles</atitle><jtitle>Journal of the American Chemical Society</jtitle><addtitle>J. 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| ispartof | Journal of the American Chemical Society, 2005-09, Vol.127 (37), p.12780-12781 |
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| source | MEDLINE; ACS Publications |
| subjects | Applied sciences Exact sciences and technology Hydrolysis Micelles Organic polymers Physicochemistry of polymers Polyesters - chemistry Polyethylene Glycols - chemistry Properties and characterization Solution and gel properties Temperature Time Factors |
| title | Hydrolytic Degradation of Poly(ethylene oxide)-block-Polycaprolactone Worm Micelles |
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