Clozapine Underutilization and Discontinuation in African Americans Due to Leucopenia

Clozapine use has been notably lower in African American patients than in Caucasians. It has been suggested that lower normal ranges for white blood cell (WBC) counts in African Americans, known as benign ethnic neutropenia, may account partially for the disparity. We examined the rates of leucopeni...

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Veröffentlicht in:	Schizophrenia bulletin 2007-09, Vol.33 (5), p.1221-1224
Hauptverfasser:	Kelly, Deanna L., Kreyenbuhl, Julie, Dixon, Lisa, Love, Raymond C., Medoff, Deborah, Conley, Robert R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult and adolescent clinical studies African Americans - genetics African Americans - statistics & numerical data Agranulocytosis - chemically induced Agranulocytosis - epidemiology Antipsychotic Agents - adverse effects Antipsychotic Agents - therapeutic use Biological and medical sciences Clozapine - adverse effects Clozapine - therapeutic use Drug Utilization - statistics & numerical data European Continental Ancestry Group - statistics & numerical data Female Hematologic and hematopoietic diseases Humans Leukocyte Count - statistics & numerical data Leukocytes - drug effects Leukopenia - chemically induced Leukopenia - epidemiology Leukopenia - genetics Male Maryland - epidemiology Medical sciences Middle Aged Neuropharmacology Other diseases. Hematologic involvement in other diseases Pharmacogenetics Pharmacology. Drug treatments Psycholeptics: tranquillizer, neuroleptic Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Psychopharmacology Psychoses Regular Schizophrenia Schizophrenia - drug therapy Treatment Outcome
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