GLI1 is regulated through Smoothened-independent mechanisms in neoplastic pancreatic ducts and mediates PDAC cell survival and transformation

Pancreatic ductal adenocarcinoma (PDAC) is characterized by the deregulation of the hedgehog signaling pathway. The Sonic Hedgehog ligand (Shh), absent in the normal pancreas, is highly expressed in pancreatic tumors and is sufficient to induce neoplastic precursor lesions in mouse models. We invest...

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Veröffentlicht in:	Genes & development 2009-01, Vol.23 (1), p.24-36
Hauptverfasser:	Nolan-Stevaux, Olivier, Lau, Janet, Truitt, Morgan L, Chu, Gerald C, Hebrok, Matthias, Fernández-Zapico, Martin E, Hanahan, Douglas
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Carcinoma, Pancreatic Ductal - genetics Carcinoma, Pancreatic Ductal - metabolism Carcinoma, Pancreatic Ductal - pathology Cell Line Cell Survival Cell Transformation, Neoplastic - metabolism Cells, Cultured Gene Expression Regulation, Neoplastic Hedgehog Proteins - genetics Hedgehog Proteins - metabolism Humans Kruppel-Like Transcription Factors - genetics Kruppel-Like Transcription Factors - metabolism Mice Pancreatic Ducts - metabolism Pancreatic Ducts - pathology Pancreatic Neoplasms - genetics Pancreatic Neoplasms - metabolism Pancreatic Neoplasms - pathology Proto-Oncogene Proteins p21(ras) - metabolism Receptors, G-Protein-Coupled - genetics Receptors, G-Protein-Coupled - metabolism Research Paper Signal Transduction Smoothened Receptor Transforming Growth Factor beta - metabolism Zinc Finger Protein GLI1
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