Role of initial protein phosphorylation events and localized release-activated calcium influx in B cell antigen receptor signaling

An increase in intracellular calcium concentration is one of the major initial steps in B cell activation following antigen receptor (BCR) ligation. We show herein that in C57BL/6 murine B lymphocytes and in model cell lines, BCR‐mediated calcium ion (Ca2+) influx occurs via highly selective Ca2+ re...

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Veröffentlicht in:	Journal of leukocyte biology 2009-02, Vol.85 (2), p.298-309
Hauptverfasser:	Lyubchenko, Taras, Nielsen, J. Paul, Miller, Sara M., Liubchenko, Ganna A., Holers, V. Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals B lymphocyte B-Lymphocytes - cytology B-Lymphocytes - immunology Ca2 Calcium - metabolism Calcium Channels Calcium Signaling - immunology Cell Membrane - metabolism Culture Media cytoplasm Cytoplasm - metabolism Extracellular Space - metabolism Immunological Synapses - immunology Intracellular Space - metabolism Ion Channels - metabolism Ion Transport Membrane Glycoproteins - metabolism Mice Mice, Inbred C57BL Phosphorylation Phosphotyrosine - metabolism Receptors, Antigen, B-Cell - immunology Receptors, Signal Transduction, and Genes signal transduction Stromal Interaction Molecule 1
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