Preclinical Characterization of a (S)-N-(4-Cyano-3-Trifluoromethyl-Phenyl)-3-(3-Fluoro, 4-Chlorophenoxy)-2-Hydroxy-2-Methyl-Propanamide: A Selective Androgen Receptor Modulator for Hormonal Male Contraception

The pharmacologic effects of (S)-N-(4-cyano-3-trifluoromethyl-phenyl)-3-(3-fluoro, 4-chlorophenoxy)-2-hydroxy-2-methyl-propanamide (S-23) were characterized in male rats as an animal model of hormonal male contraception. S-23 showed high binding affinity (inhibitory constant = 1.7 ± 0.2 nm) and was...

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Veröffentlicht in:	Endocrinology (Philadelphia) 2009-01, Vol.150 (1), p.385-395
Hauptverfasser:	Jones, Amanda, Chen, Jiyun, Hwang, Dong Jin, Miller, Duane D, Dalton, James T
Format:	Artikel
Sprache:	eng
Schlagworte:	17β-Estradiol Androgen receptors Androgens Anilides - metabolism Anilides - pharmacology Animal models Animals Benzoates Biological and medical sciences Birth control Body Composition - drug effects Body fat Bone mass Bone mineral density Contraception Contraceptive Agents, Male - pharmacokinetics Contraceptive Agents, Male - pharmacology Estradiol - analogs & derivatives Estradiol - pharmacology Female Follicle-stimulating hormone Fundamental and applied biological sciences. Psychology Infertility Male Males Muscle, Skeletal - drug effects Muscle, Skeletal - physiology Muscles Orchiectomy Organ Size - drug effects Pharmacokinetics Pregnancy Prostate Prostate - drug effects Prostate - physiology Rats Rats, Sprague-Dawley Receptor density Receptors Receptors, Androgen - drug effects Receptors, Androgen - genetics Seminal Vesicles - drug effects Seminal Vesicles - physiology Sex hormones Sexual behavior Sexual Behavior, Animal - drug effects Sexual Behavior, Animal - physiology Spermatogenesis Spermatogenesis - drug effects Vertebrates: endocrinology
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