Effect of Variation in CHI3L1 on Serum YKL-40 Level, Risk of Asthma, and Lung Function
The chitinase-like protein YKL-40 is known to be involved in inflammation and tissue remodeling and is a biomarker of asthma severity and pulmonary function. This study shows an association between markers in the gene encoding YKL-40 and asthma, indicating that YKL-40 levels not only serve as a biom...
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| Veröffentlicht in: | The New England journal of medicine 2008-04, Vol.358 (16), p.1682-1691 |
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| creator | Ober, Carole Tan, Zheng Sun, Ying Possick, Jennifer D Pan, Lin Nicolae, Raluca Nicolae, Dan L Radford, Sadie Parry, Rodney R Heinzmann, Andrea Deichmann, Klaus A Lester, Lucille A Gern, James E Lemanske, Robert F Elias, Jack A Chupp, Geoffrey L |
| description | The chitinase-like protein YKL-40 is known to be involved in inflammation and tissue remodeling and is a biomarker of asthma severity and pulmonary function. This study shows an association between markers in the gene encoding YKL-40 and asthma, indicating that YKL-40 levels not only serve as a biomarker but also contribute to disease susceptibility.
This study shows an association between markers in the gene encoding YKL-40 and asthma, indicating that YKL-40 levels not only serve as a biomarker but also contribute to disease susceptibility.
Chitinases are evolutionarily conserved proteins that mediate airway inflammation in mouse models of asthma.
1
The chitinase-like protein YKL-40 lacks chitinase activity but binds ubiquitously expressed chitin and has been implicated in inflammation and tissue remodeling.
2
–
6
We recently demonstrated that serum YKL-40 levels are elevated in patients with asthma and that circulating YKL-40 levels are correlated with asthma severity, thickness of the subepithelial basement membrane, and pulmonary function,
7
suggesting that circulating YKL-40 levels are a biomarker for asthma. The YKL-40 protein is encoded by the chitinase 3–like 1 gene
CHI3L1,
and single-nucleotide polymorphisms (SNPs) in the
CHI3L1
promoter have been . . . |
| doi_str_mv | 10.1056/NEJMoa0708801 |
| format | Article |
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This study shows an association between markers in the gene encoding YKL-40 and asthma, indicating that YKL-40 levels not only serve as a biomarker but also contribute to disease susceptibility.
Chitinases are evolutionarily conserved proteins that mediate airway inflammation in mouse models of asthma.
1
The chitinase-like protein YKL-40 lacks chitinase activity but binds ubiquitously expressed chitin and has been implicated in inflammation and tissue remodeling.
2
–
6
We recently demonstrated that serum YKL-40 levels are elevated in patients with asthma and that circulating YKL-40 levels are correlated with asthma severity, thickness of the subepithelial basement membrane, and pulmonary function,
7
suggesting that circulating YKL-40 levels are a biomarker for asthma. The YKL-40 protein is encoded by the chitinase 3–like 1 gene
CHI3L1,
and single-nucleotide polymorphisms (SNPs) in the
CHI3L1
promoter have been . . .</description><identifier>ISSN: 0028-4793</identifier><identifier>EISSN: 1533-4406</identifier><identifier>DOI: 10.1056/NEJMoa0708801</identifier><identifier>PMID: 18403759</identifier><identifier>CODEN: NEJMAG</identifier><language>eng</language><publisher>Boston, MA: Massachusetts Medical Society</publisher><subject>Adipokines ; Adolescent ; Adult ; Age ; Aged ; Aged, 80 and over ; Asthma ; Asthma - blood ; Asthma - genetics ; Biological and medical sciences ; Biomarkers - blood ; Bronchial Hyperreactivity - blood ; Bronchial Hyperreactivity - genetics ; Case-Control Studies ; Child ; Chitinase ; Chitinase-3-Like Protein 1 ; Chronic obstructive pulmonary disease, asthma ; Female ; Founder Effect ; General aspects ; Genetic Predisposition to Disease ; Genetics ; Genotype ; Glycoproteins - blood ; Glycoproteins - genetics ; Humans ; Lectins ; Male ; Medical sciences ; Middle Aged ; Phenotype ; Pneumology ; Polymorphism, Single Nucleotide ; Pulmonary Ventilation - genetics ; Studies</subject><ispartof>The New England journal of medicine, 2008-04, Vol.358 (16), p.1682-1691</ispartof><rights>Copyright © 2008 Massachusetts Medical Society. All rights reserved.</rights><rights>2008 INIST-CNRS</rights><rights>Copyright 2008 Massachusetts Medical Society.</rights><rights>Copyright © 2008 Massachusetts Medical Society. 2008</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c524t-2b1049f4f992980f63787182a51954d337edf5a4292dc6042f9fb0cd4b1a096b3</citedby><cites>FETCH-LOGICAL-c524t-2b1049f4f992980f63787182a51954d337edf5a4292dc6042f9fb0cd4b1a096b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.nejm.org/doi/pdf/10.1056/NEJMoa0708801$$EPDF$$P50$$Gmms$$H</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/223923396?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>230,314,780,784,885,2758,2759,26102,27923,27924,52381,54063,64384,64386,64388,72340</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20277723$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18403759$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ober, Carole</creatorcontrib><creatorcontrib>Tan, Zheng</creatorcontrib><creatorcontrib>Sun, Ying</creatorcontrib><creatorcontrib>Possick, Jennifer D</creatorcontrib><creatorcontrib>Pan, Lin</creatorcontrib><creatorcontrib>Nicolae, Raluca</creatorcontrib><creatorcontrib>Nicolae, Dan L</creatorcontrib><creatorcontrib>Radford, Sadie</creatorcontrib><creatorcontrib>Parry, Rodney R</creatorcontrib><creatorcontrib>Heinzmann, Andrea</creatorcontrib><creatorcontrib>Deichmann, Klaus A</creatorcontrib><creatorcontrib>Lester, Lucille A</creatorcontrib><creatorcontrib>Gern, James E</creatorcontrib><creatorcontrib>Lemanske, Robert F</creatorcontrib><creatorcontrib>Elias, Jack A</creatorcontrib><creatorcontrib>Chupp, Geoffrey L</creatorcontrib><title>Effect of Variation in CHI3L1 on Serum YKL-40 Level, Risk of Asthma, and Lung Function</title><title>The New England journal of medicine</title><addtitle>N Engl J Med</addtitle><description>The chitinase-like protein YKL-40 is known to be involved in inflammation and tissue remodeling and is a biomarker of asthma severity and pulmonary function. This study shows an association between markers in the gene encoding YKL-40 and asthma, indicating that YKL-40 levels not only serve as a biomarker but also contribute to disease susceptibility.
This study shows an association between markers in the gene encoding YKL-40 and asthma, indicating that YKL-40 levels not only serve as a biomarker but also contribute to disease susceptibility.
Chitinases are evolutionarily conserved proteins that mediate airway inflammation in mouse models of asthma.
1
The chitinase-like protein YKL-40 lacks chitinase activity but binds ubiquitously expressed chitin and has been implicated in inflammation and tissue remodeling.
2
–
6
We recently demonstrated that serum YKL-40 levels are elevated in patients with asthma and that circulating YKL-40 levels are correlated with asthma severity, thickness of the subepithelial basement membrane, and pulmonary function,
7
suggesting that circulating YKL-40 levels are a biomarker for asthma. The YKL-40 protein is encoded by the chitinase 3–like 1 gene
CHI3L1,
and single-nucleotide polymorphisms (SNPs) in the
CHI3L1
promoter have been . . .</description><subject>Adipokines</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Age</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Asthma</subject><subject>Asthma - blood</subject><subject>Asthma - genetics</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - blood</subject><subject>Bronchial Hyperreactivity - blood</subject><subject>Bronchial Hyperreactivity - genetics</subject><subject>Case-Control Studies</subject><subject>Child</subject><subject>Chitinase</subject><subject>Chitinase-3-Like Protein 1</subject><subject>Chronic obstructive pulmonary disease, asthma</subject><subject>Female</subject><subject>Founder Effect</subject><subject>General aspects</subject><subject>Genetic Predisposition to Disease</subject><subject>Genetics</subject><subject>Genotype</subject><subject>Glycoproteins - blood</subject><subject>Glycoproteins - genetics</subject><subject>Humans</subject><subject>Lectins</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Phenotype</subject><subject>Pneumology</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Pulmonary Ventilation - genetics</subject><subject>Studies</subject><issn>0028-4793</issn><issn>1533-4406</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp1kdtrFDEUh4NY7Lb66KsEwT51NLfJ5UUoy9a2jgpeCj6FTCZps84kbTJT6H_vLF1WK5iXEM6X75zDD4CXGL3FqObvPq8uPiWDBJIS4SdggWtKK8YQfwoWCBFZMaHoPjgoZY3mg5l6BvaxZIiKWi3A5cp7Z0eYPLw0OZgxpAhDhMuzc9pgOD--uTwN8OfHpmIINu7O9cfwayi_Nl9Oyng9mGNoYgebKV7B0ynajeI52POmL-7F9j4EP05X35dnVfPlw_nypKlsTdhYkRYjpjzzShElkedUSIElMTVWNesoFa7ztWFEkc5yxIhXvkW2Yy02SPGWHoL3D96bqR1cZ10cs-n1TQ6Dyfc6maAfV2K41lfpThNOFJN8FhxtBTndTq6MegjFur430aWpaK4w5lKJGXz9D7hOU47zcpoQqgilamOrHiCbUynZ-d0kGOlNXPpRXDP_6u_x_9DbfGbgzRYwxZreZxNtKDuOICKEmHvvuGEoOrr18J-GvwF5iKUt</recordid><startdate>20080417</startdate><enddate>20080417</enddate><creator>Ober, Carole</creator><creator>Tan, Zheng</creator><creator>Sun, Ying</creator><creator>Possick, Jennifer D</creator><creator>Pan, Lin</creator><creator>Nicolae, Raluca</creator><creator>Nicolae, Dan L</creator><creator>Radford, Sadie</creator><creator>Parry, Rodney R</creator><creator>Heinzmann, Andrea</creator><creator>Deichmann, Klaus A</creator><creator>Lester, Lucille A</creator><creator>Gern, James E</creator><creator>Lemanske, Robert F</creator><creator>Elias, Jack A</creator><creator>Chupp, Geoffrey L</creator><general>Massachusetts Medical Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0TZ</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K0Y</scope><scope>LK8</scope><scope>M0R</scope><scope>M0T</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>M2P</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20080417</creationdate><title>Effect of Variation in CHI3L1 on Serum YKL-40 Level, Risk of Asthma, and Lung Function</title><author>Ober, Carole ; Tan, Zheng ; Sun, Ying ; Possick, Jennifer D ; Pan, Lin ; Nicolae, Raluca ; Nicolae, Dan L ; Radford, Sadie ; Parry, Rodney R ; Heinzmann, Andrea ; Deichmann, Klaus A ; Lester, Lucille A ; Gern, James E ; Lemanske, Robert F ; Elias, Jack A ; Chupp, Geoffrey L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c524t-2b1049f4f992980f63787182a51954d337edf5a4292dc6042f9fb0cd4b1a096b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adipokines</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Age</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Asthma</topic><topic>Asthma - blood</topic><topic>Asthma - genetics</topic><topic>Biological and medical sciences</topic><topic>Biomarkers - blood</topic><topic>Bronchial Hyperreactivity - blood</topic><topic>Bronchial Hyperreactivity - genetics</topic><topic>Case-Control Studies</topic><topic>Child</topic><topic>Chitinase</topic><topic>Chitinase-3-Like Protein 1</topic><topic>Chronic obstructive pulmonary disease, asthma</topic><topic>Female</topic><topic>Founder Effect</topic><topic>General aspects</topic><topic>Genetic Predisposition to Disease</topic><topic>Genetics</topic><topic>Genotype</topic><topic>Glycoproteins - blood</topic><topic>Glycoproteins - genetics</topic><topic>Humans</topic><topic>Lectins</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Phenotype</topic><topic>Pneumology</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Pulmonary Ventilation - genetics</topic><topic>Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ober, Carole</creatorcontrib><creatorcontrib>Tan, Zheng</creatorcontrib><creatorcontrib>Sun, Ying</creatorcontrib><creatorcontrib>Possick, Jennifer D</creatorcontrib><creatorcontrib>Pan, Lin</creatorcontrib><creatorcontrib>Nicolae, Raluca</creatorcontrib><creatorcontrib>Nicolae, Dan L</creatorcontrib><creatorcontrib>Radford, Sadie</creatorcontrib><creatorcontrib>Parry, Rodney R</creatorcontrib><creatorcontrib>Heinzmann, Andrea</creatorcontrib><creatorcontrib>Deichmann, Klaus A</creatorcontrib><creatorcontrib>Lester, Lucille A</creatorcontrib><creatorcontrib>Gern, James E</creatorcontrib><creatorcontrib>Lemanske, Robert F</creatorcontrib><creatorcontrib>Elias, Jack A</creatorcontrib><creatorcontrib>Chupp, Geoffrey L</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Pharma and Biotech Premium PRO</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>eLibrary</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>New England Journal of Medicine</collection><collection>ProQuest Biological Science Collection</collection><collection>Consumer Health Database</collection><collection>Healthcare Administration Database</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>Research Library</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The New England journal of medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ober, Carole</au><au>Tan, Zheng</au><au>Sun, Ying</au><au>Possick, Jennifer D</au><au>Pan, Lin</au><au>Nicolae, Raluca</au><au>Nicolae, Dan L</au><au>Radford, Sadie</au><au>Parry, Rodney R</au><au>Heinzmann, Andrea</au><au>Deichmann, Klaus A</au><au>Lester, Lucille A</au><au>Gern, James E</au><au>Lemanske, Robert F</au><au>Elias, Jack A</au><au>Chupp, Geoffrey L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of Variation in CHI3L1 on Serum YKL-40 Level, Risk of Asthma, and Lung Function</atitle><jtitle>The New England journal of medicine</jtitle><addtitle>N Engl J Med</addtitle><date>2008-04-17</date><risdate>2008</risdate><volume>358</volume><issue>16</issue><spage>1682</spage><epage>1691</epage><pages>1682-1691</pages><issn>0028-4793</issn><eissn>1533-4406</eissn><coden>NEJMAG</coden><abstract>The chitinase-like protein YKL-40 is known to be involved in inflammation and tissue remodeling and is a biomarker of asthma severity and pulmonary function. This study shows an association between markers in the gene encoding YKL-40 and asthma, indicating that YKL-40 levels not only serve as a biomarker but also contribute to disease susceptibility.
This study shows an association between markers in the gene encoding YKL-40 and asthma, indicating that YKL-40 levels not only serve as a biomarker but also contribute to disease susceptibility.
Chitinases are evolutionarily conserved proteins that mediate airway inflammation in mouse models of asthma.
1
The chitinase-like protein YKL-40 lacks chitinase activity but binds ubiquitously expressed chitin and has been implicated in inflammation and tissue remodeling.
2
–
6
We recently demonstrated that serum YKL-40 levels are elevated in patients with asthma and that circulating YKL-40 levels are correlated with asthma severity, thickness of the subepithelial basement membrane, and pulmonary function,
7
suggesting that circulating YKL-40 levels are a biomarker for asthma. The YKL-40 protein is encoded by the chitinase 3–like 1 gene
CHI3L1,
and single-nucleotide polymorphisms (SNPs) in the
CHI3L1
promoter have been . . .</abstract><cop>Boston, MA</cop><pub>Massachusetts Medical Society</pub><pmid>18403759</pmid><doi>10.1056/NEJMoa0708801</doi><tpages>10</tpages></addata></record> |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; ProQuest Central UK/Ireland; New England Journal of Medicine |
| subjects | Adipokines Adolescent Adult Age Aged Aged, 80 and over Asthma Asthma - blood Asthma - genetics Biological and medical sciences Biomarkers - blood Bronchial Hyperreactivity - blood Bronchial Hyperreactivity - genetics Case-Control Studies Child Chitinase Chitinase-3-Like Protein 1 Chronic obstructive pulmonary disease, asthma Female Founder Effect General aspects Genetic Predisposition to Disease Genetics Genotype Glycoproteins - blood Glycoproteins - genetics Humans Lectins Male Medical sciences Middle Aged Phenotype Pneumology Polymorphism, Single Nucleotide Pulmonary Ventilation - genetics Studies |
| title | Effect of Variation in CHI3L1 on Serum YKL-40 Level, Risk of Asthma, and Lung Function |
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