Corticotropin-Releasing Factor Increases GABA Synaptic Activity and Induces Inward Current in 5-Hydroxytryptamine Dorsal Raphe Neurons

Stress-related psychiatric disorders such as anxiety and depression involve dysfunction of the serotonin [5-hydroxytryptamine (5-HT)] system. Previous studies have found that the stress neurohormone corticotropin-releasing factor (CRF) inhibits 5-HT neurons in the dorsal raphe nucleus (DRN) in vivo....

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Veröffentlicht in:	The Journal of neuroscience 2008-11, Vol.28 (48), p.12927-12937
Hauptverfasser:	Kirby, Lynn G, Freeman-Daniels, Emily, Lemos, Julia C, Nunan, John D, Lamy, Christophe, Akanwa, Adaure, Beck, Sheryl G
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Membrane - drug effects Cell Membrane - metabolism Corticotropin-Releasing Hormone - metabolism Corticotropin-Releasing Hormone - pharmacology gamma-Aminobutyric Acid - metabolism Inhibitory Postsynaptic Potentials - drug effects Inhibitory Postsynaptic Potentials - physiology Male Mesencephalon - drug effects Mesencephalon - metabolism Neural Inhibition - drug effects Neural Inhibition - physiology Neurons - drug effects Neurons - metabolism Organ Culture Techniques Patch-Clamp Techniques Raphe Nuclei - drug effects Raphe Nuclei - metabolism Rats Rats, Sprague-Dawley Receptors, Corticotropin-Releasing Hormone - agonists Receptors, Corticotropin-Releasing Hormone - antagonists & inhibitors Receptors, Corticotropin-Releasing Hormone - metabolism Serotonin - metabolism Synapses - drug effects Synapses - metabolism Synaptic Transmission - drug effects Synaptic Transmission - physiology
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