The RON receptor tyrosine kinase promotes MSP-independent cell spreading and survival in breast epithelial cells

The recepteur d'origine nantais (RON) is a receptor tyrosine kinase (RTK) in the scatter factor family, which includes the c-Met receptor. RON exhibits increased expression in a significant number of human breast cancer tissues as well as in many established breast cancer cell lines. Recent stu...

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Veröffentlicht in:	Oncogene 2009-01, Vol.28 (2), p.279-288
Hauptverfasser:	Feres, K J, Ischenko, I, Hayman, M J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Biological and medical sciences Breast - cytology Breast cancer Cell Adhesion - drug effects Cell Adhesion - physiology Cell Biology Cell cycle Cell Division - drug effects Cell Division - physiology Cell growth Cell Line - cytology Cell Line - drug effects Cell Line - enzymology Cell Line, Transformed - cytology Cell Line, Transformed - drug effects Cell Line, Transformed - enzymology Cell Movement - drug effects Cell Movement - physiology Cell physiology Cell receptors Cell Shape - drug effects Cell Shape - physiology Cell structures and functions Cell Survival - drug effects Cell Survival - physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Cell Transformation, Neoplastic Cellular signal transduction Epithelial Cells - cytology Epithelial Cells - drug effects Epithelial Cells - enzymology Female Fundamental and applied biological sciences. Psychology Genetic aspects Gynecology. Andrology. Obstetrics Health aspects Hepatocyte Growth Factor - physiology Human Genetics Humans Internal Medicine Kinases Mammary gland diseases Medical sciences Medicine Medicine & Public Health Mice Miscellaneous Molecular and cellular biology NIH 3T3 Cells - cytology NIH 3T3 Cells - drug effects Oncology original-article Phosphatidylinositol 3-Kinases - antagonists & inhibitors Phosphatidylinositol 3-Kinases - physiology Phosphorylation - drug effects Physiological aspects Protein Kinase Inhibitors - pharmacology Protein Processing, Post-Translational - drug effects Protein tyrosine kinase Proto-Oncogene Proteins - physiology Proto-Oncogene Proteins c-akt - antagonists & inhibitors Proto-Oncogene Proteins c-akt - physiology Receptor Protein-Tyrosine Kinases - genetics Receptor Protein-Tyrosine Kinases - physiology Risk factors Signal transduction Signal Transduction - drug effects Signal Transduction - physiology src-Family Kinases - physiology Tumors
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