The multi-tasking P-TEFb complex

P-TEFb (CycT1:Cdk9), the metazoan RNA polymerase II Ser2 C-terminal domain (CTD) kinase, regulates transcription elongation at many genes and integrates mRNA synthesis with histone modification, pre-mRNA processing, and mRNA export. Recruitment of P-TEFb to target genes requires deubiquitination of...

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Veröffentlicht in:	Current opinion in cell biology 2008-06, Vol.20 (3), p.334-340
Hauptverfasser:	Brès, Vanessa, Yoh, Sunnie M, Jones, Katherine A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Histones - genetics Histones - metabolism Humans Internal Medicine Metazoa Methylation Nuclear Proteins - genetics Nuclear Proteins - metabolism Phosphoric Monoester Hydrolases - genetics Phosphoric Monoester Hydrolases - metabolism Positive Transcriptional Elongation Factor B - genetics Positive Transcriptional Elongation Factor B - metabolism Protein Biosynthesis - genetics RNA, Messenger - biosynthesis RNA, Messenger - genetics Transcription Factors - genetics Transcription Factors - metabolism Transcription, Genetic - genetics
Online-Zugang:	Volltext
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