Synchronous adenocarcinoma and mantle cell lymphoma of the stomach
Synchronous occurrence of mantle cell lymphoma (MCL) and gastric cancer in the same patient has not yet been reported in the English literature. MCL comprises 2.5-7% of non-Hodgkin's lymphomas and is characterized by a poor prognosis with a median survival probability of 3-4 years in most serie...
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| Veröffentlicht in: | Yonsei medical journal 2007-12, Vol.48 (6), p.1061-1065 |
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| description | Synchronous occurrence of mantle cell lymphoma (MCL) and gastric cancer in the same patient has not yet been reported in the English literature. MCL comprises 2.5-7% of non-Hodgkin's lymphomas and is characterized by a poor prognosis with a median survival probability of 3-4 years in most series. A 62-year-old man was referred to our hospital for evaluation of an abnormal gastric lesion. The endoscopic finding was compatible with type IIc early gastric cancer (EGC) in the middle third of the stomach, and a biopsy of the lesion proved to be carcinoma. Radical total gastrectomy with splenectomy and Roux-en-Y esophagojejunostomy were performed. The resected specimen revealed two grossly separated lesions. Postoperative histological examination reported both adenocarcinoma and MCL. Immunohistochemical staining showed positivity for CD5, CD20, and cyclin D1 in the infiltrated lymphoid cells. MCL is an aggressive non-Hodgkin's lymphoma, and the current treatment approach is still unsatisfactory. Further advancements in the understanding of the synchronous occurrence of both diseases, and more efforts on investigations of treatment are needed. |
| doi_str_mv | 10.3349/ymj.2007.48.6.1061 |
| format | Article |
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MCL comprises 2.5-7% of non-Hodgkin's lymphomas and is characterized by a poor prognosis with a median survival probability of 3-4 years in most series. A 62-year-old man was referred to our hospital for evaluation of an abnormal gastric lesion. The endoscopic finding was compatible with type IIc early gastric cancer (EGC) in the middle third of the stomach, and a biopsy of the lesion proved to be carcinoma. Radical total gastrectomy with splenectomy and Roux-en-Y esophagojejunostomy were performed. The resected specimen revealed two grossly separated lesions. Postoperative histological examination reported both adenocarcinoma and MCL. Immunohistochemical staining showed positivity for CD5, CD20, and cyclin D1 in the infiltrated lymphoid cells. MCL is an aggressive non-Hodgkin's lymphoma, and the current treatment approach is still unsatisfactory. Further advancements in the understanding of the synchronous occurrence of both diseases, and more efforts on investigations of treatment are needed.</description><identifier>ISSN: 0513-5796</identifier><identifier>EISSN: 1976-2437</identifier><identifier>DOI: 10.3349/ymj.2007.48.6.1061</identifier><identifier>PMID: 18159604</identifier><language>eng</language><publisher>Korea (South): Yonsei University College of Medicine</publisher><subject>Adenocarcinoma - complications ; Adenocarcinoma - metabolism ; Adenocarcinoma - pathology ; Antigens, CD20 - analysis ; Case Report ; CD5 Antigens - analysis ; Cyclin D1 - analysis ; Humans ; Immunohistochemistry ; Lymphoma, Mantle-Cell - complications ; Lymphoma, Mantle-Cell - metabolism ; Lymphoma, Mantle-Cell - pathology ; Male ; Middle Aged ; Stomach - chemistry ; Stomach - pathology ; Stomach Neoplasms - complications ; Stomach Neoplasms - metabolism ; Stomach Neoplasms - pathology</subject><ispartof>Yonsei medical journal, 2007-12, Vol.48 (6), p.1061-1065</ispartof><rights>Copyright © 2007 The Yonsei University College of Medicine 2007</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c400t-106ae2150712e21222e518c71e2afc0b1601a1a7cc882f933bf3014f29ae428c3</citedby><cites>FETCH-LOGICAL-c400t-106ae2150712e21222e518c71e2afc0b1601a1a7cc882f933bf3014f29ae428c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2628182/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2628182/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,725,778,782,862,883,27911,27912,53778,53780</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18159604$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kim, Yong Il</creatorcontrib><creatorcontrib>Koo, Min Young</creatorcontrib><title>Synchronous adenocarcinoma and mantle cell lymphoma of the stomach</title><title>Yonsei medical journal</title><addtitle>Yonsei Med J</addtitle><description>Synchronous occurrence of mantle cell lymphoma (MCL) and gastric cancer in the same patient has not yet been reported in the English literature. MCL comprises 2.5-7% of non-Hodgkin's lymphomas and is characterized by a poor prognosis with a median survival probability of 3-4 years in most series. A 62-year-old man was referred to our hospital for evaluation of an abnormal gastric lesion. The endoscopic finding was compatible with type IIc early gastric cancer (EGC) in the middle third of the stomach, and a biopsy of the lesion proved to be carcinoma. Radical total gastrectomy with splenectomy and Roux-en-Y esophagojejunostomy were performed. The resected specimen revealed two grossly separated lesions. Postoperative histological examination reported both adenocarcinoma and MCL. Immunohistochemical staining showed positivity for CD5, CD20, and cyclin D1 in the infiltrated lymphoid cells. MCL is an aggressive non-Hodgkin's lymphoma, and the current treatment approach is still unsatisfactory. Further advancements in the understanding of the synchronous occurrence of both diseases, and more efforts on investigations of treatment are needed.</description><subject>Adenocarcinoma - complications</subject><subject>Adenocarcinoma - metabolism</subject><subject>Adenocarcinoma - pathology</subject><subject>Antigens, CD20 - analysis</subject><subject>Case Report</subject><subject>CD5 Antigens - analysis</subject><subject>Cyclin D1 - analysis</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Lymphoma, Mantle-Cell - complications</subject><subject>Lymphoma, Mantle-Cell - metabolism</subject><subject>Lymphoma, Mantle-Cell - pathology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Stomach - chemistry</subject><subject>Stomach - pathology</subject><subject>Stomach Neoplasms - complications</subject><subject>Stomach Neoplasms - metabolism</subject><subject>Stomach Neoplasms - pathology</subject><issn>0513-5796</issn><issn>1976-2437</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkE1LxDAQhoMoun78AQ_Sk7fWmUmbpBdBxS9Y8KCeQzab2kqbrE1X2H9vi4sfp2F4Z95552HsFCHjPC8vNt17RgAyy1UmMgSBO2yGpRQp5VzushkUyNNCluKAHcb4DkASgfbZASosSgH5jF0_b7yt--DDOiZm6XywpreND51JjF8mnfFD6xLr2jZpN92qnoRQJUPtkjiMja2P2V5l2uhOtvWIvd7dvtw8pPOn-8ebq3lqc4AhHfMZR1iARBorEbkClZXoyFQWFigADRpprVJUlZwvKg6YV1Qal5Oy_Ihdfvuu1ovOLa3zQ29aveqbzvQbHUyj_yu-qfVb-NQkSKGi0eB8a9CHj7WLg-6aOH1mvBvf16IEqcqCj4P0PWj7EGPvqp8jCHpCr0f0ekKvc6WFntCPS2d_4_2ubFnzL0A_gQc</recordid><startdate>20071231</startdate><enddate>20071231</enddate><creator>Kim, Yong Il</creator><creator>Koo, Min Young</creator><general>Yonsei University College of Medicine</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20071231</creationdate><title>Synchronous adenocarcinoma and mantle cell lymphoma of the stomach</title><author>Kim, Yong Il ; Koo, Min Young</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c400t-106ae2150712e21222e518c71e2afc0b1601a1a7cc882f933bf3014f29ae428c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adenocarcinoma - complications</topic><topic>Adenocarcinoma - metabolism</topic><topic>Adenocarcinoma - pathology</topic><topic>Antigens, CD20 - analysis</topic><topic>Case Report</topic><topic>CD5 Antigens - analysis</topic><topic>Cyclin D1 - analysis</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Lymphoma, Mantle-Cell - complications</topic><topic>Lymphoma, Mantle-Cell - metabolism</topic><topic>Lymphoma, Mantle-Cell - pathology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Stomach - chemistry</topic><topic>Stomach - pathology</topic><topic>Stomach Neoplasms - complications</topic><topic>Stomach Neoplasms - metabolism</topic><topic>Stomach Neoplasms - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kim, Yong Il</creatorcontrib><creatorcontrib>Koo, Min Young</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Yonsei medical journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kim, Yong Il</au><au>Koo, Min Young</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Synchronous adenocarcinoma and mantle cell lymphoma of the stomach</atitle><jtitle>Yonsei medical journal</jtitle><addtitle>Yonsei Med J</addtitle><date>2007-12-31</date><risdate>2007</risdate><volume>48</volume><issue>6</issue><spage>1061</spage><epage>1065</epage><pages>1061-1065</pages><issn>0513-5796</issn><eissn>1976-2437</eissn><abstract>Synchronous occurrence of mantle cell lymphoma (MCL) and gastric cancer in the same patient has not yet been reported in the English literature. MCL comprises 2.5-7% of non-Hodgkin's lymphomas and is characterized by a poor prognosis with a median survival probability of 3-4 years in most series. A 62-year-old man was referred to our hospital for evaluation of an abnormal gastric lesion. The endoscopic finding was compatible with type IIc early gastric cancer (EGC) in the middle third of the stomach, and a biopsy of the lesion proved to be carcinoma. Radical total gastrectomy with splenectomy and Roux-en-Y esophagojejunostomy were performed. The resected specimen revealed two grossly separated lesions. Postoperative histological examination reported both adenocarcinoma and MCL. Immunohistochemical staining showed positivity for CD5, CD20, and cyclin D1 in the infiltrated lymphoid cells. MCL is an aggressive non-Hodgkin's lymphoma, and the current treatment approach is still unsatisfactory. Further advancements in the understanding of the synchronous occurrence of both diseases, and more efforts on investigations of treatment are needed.</abstract><cop>Korea (South)</cop><pub>Yonsei University College of Medicine</pub><pmid>18159604</pmid><doi>10.3349/ymj.2007.48.6.1061</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| source | KoreaMed Synapse; MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central Open Access; KoreaMed Open Access; PubMed Central |
| subjects | Adenocarcinoma - complications Adenocarcinoma - metabolism Adenocarcinoma - pathology Antigens, CD20 - analysis Case Report CD5 Antigens - analysis Cyclin D1 - analysis Humans Immunohistochemistry Lymphoma, Mantle-Cell - complications Lymphoma, Mantle-Cell - metabolism Lymphoma, Mantle-Cell - pathology Male Middle Aged Stomach - chemistry Stomach - pathology Stomach Neoplasms - complications Stomach Neoplasms - metabolism Stomach Neoplasms - pathology |
| title | Synchronous adenocarcinoma and mantle cell lymphoma of the stomach |
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