One-Month Diesel Exhaust Inhalation Produces Hypertensive Gene Expression Pattern in Healthy Rats

Background: Exposure to diesel exhaust (DE) is linked to vasoconstriction, endothelial dysfunction, and myocardial ischemia in compromised individuals. Objective: We hypothesized that DE inhalation would cause greater inflammation, hematologic alterations, and cardiac molecular impairment in spontan...

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Veröffentlicht in:	Environmental health perspectives 2009-01, Vol.117 (1), p.38-46
Hauptverfasser:	Gottipolu, Ready R., Wallenborn, J. Grace, Karoly, Edward D., Schladweiler, Mette C., Ledbetter, Allen D., Krantz, Todd, Linak, William P., Nyska, Abraham, Johnson, Jo Anne, Thomas, Ronald, Richards, Judy E., Jaskot, Richard H., Kodavanti, Urmila P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Air pollution Alterations Animals Complications and side effects Diesel Diesel exhaust Diesel fuels Diesel motor exhaust gas Diseases Endothelium Environmental agencies Environmental aspects Environmental health Exhaust Fluid dynamics Fluid flow Gene expression Gene Expression Regulation Genes Genetic aspects Health Health aspects Heart Hypertension - genetics Impairment Inhalation Ischemia Lungs Macrophages Male Markers Microscopy, Electron, Transmission Mitochondria Myocardial ischemia Oxidative stress Rats Rats, Inbred SHR Rats, Inbred WKY Risk factors Strain Stresses Vasoconstriction Vehicle Emissions - toxicity Zinc
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