The risk of extra‐colonic, extra‐endometrial cancer in the Lynch syndrome

Persons with the Lynch syndrome (LS) are at high risk for cancer, including cancers of the small bowel, stomach, upper urologic tract (renal pelvis and ureter), ovary, biliary tract and brain tumors, in addition to the more commonly observed colorectal and endometrial cancers. Cancer prevention stra...

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Veröffentlicht in:	International journal of cancer 2008-07, Vol.123 (2), p.444-449
Hauptverfasser:	Watson, Patrice, Vasen, Hans F.A., Mecklin, Jukka‐Pekka, Bernstein, Inge, Aarnio, Markku, Järvinen, Heikki J., Myrhøj, Torben, Sunde, Lone, Wijnen, Juul T., Lynch, Henry T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - genetics Adult Age Distribution Age Factors Aged Aged, 80 and over Biological and medical sciences cancer risk Colorectal Neoplasms, Hereditary Nonpolyposis - genetics Confounding Factors (Epidemiology) Denmark - epidemiology DNA Mismatch Repair Female Finland - epidemiology Gastroenterology. Liver. Pancreas. Abdomen Humans Incidence Kaplan-Meier Estimate Lynch syndrome Male Medical sciences Middle Aged MLH1 MSH2 Multivariate Analysis Mutation MutL Protein Homolog 1 MutS Homolog 2 Protein - genetics Neoplasms - epidemiology Neoplasms - genetics Netherlands - epidemiology Nuclear Proteins - genetics Odds Ratio Ovarian Neoplasms - epidemiology Ovarian Neoplasms - genetics Proportional Hazards Models Registries Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Tumors United States - epidemiology Urologic Neoplasms - epidemiology Urologic Neoplasms - genetics
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