Radiolabeled Phenethylguanidines: Novel Imaging Agents for Cardiac Sympathetic Neurons and Adrenergic Tumors

The norepinephrine transporter (NET) substrates [123I]-m-iodobenzylguanidine (MIBG) and [11C]-m-hydroxyephedrine (HED) are used as markers of cardiac sympathetic neurons and adrenergic tumors (pheochromocytoma, neuroblastoma). However, their rapid NET transport rates limit their ability to provide a...

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Veröffentlicht in:	Journal of medicinal chemistry 2007-05, Vol.50 (9), p.2078-2088
Hauptverfasser:	Raffel, David M, Jung, Yong-Woon, Gildersleeve, David L, Sherman, Phillip S, Moskwa, James J, Tluczek, Louis J, Chen, Wei
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenal Gland Neoplasms - diagnostic imaging Animals Biological and medical sciences Carbon Radioisotopes Contrast media. Radiopharmaceuticals Guanidines - chemical synthesis Guanidines - chemistry Guanidines - pharmacokinetics Guanidines - pharmacology Guanine - analogs & derivatives Guanine - chemical synthesis Guanine - chemistry Guanine - pharmacokinetics Heart - diagnostic imaging Heart - innervation In Vitro Techniques Macaca mulatta Male Medical sciences Mice Mice, Nude Neurons - metabolism Norepinephrine Plasma Membrane Transport Proteins - metabolism Octopamine - analogs & derivatives Octopamine - chemical synthesis Octopamine - chemistry Octopamine - pharmacokinetics Pharmacology. Drug treatments Pheochromocytoma Positron-Emission Tomography Primates Radiopharmaceuticals - chemical synthesis Radiopharmaceuticals - chemistry Radiopharmaceuticals - pharmacology Rats Structure-Activity Relationship Sympathetic Nervous System - cytology Sympathetic Nervous System - metabolism Tissue Distribution Xenograft Model Antitumor Assays
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