Differential global and extra-cellular matrix focused gene expression patterns between normal and glaucomatous human lamina cribrosa cells

Marked extracellular matrix (ECM) remodeling occurs in the human optic nerve head in primary open angle glaucoma (POAG). The glial fibrillary acid protein (GFAP) negative lamina cribrosa cell may play an important role in this remodeling process. We report the first study of global and ECM-focused g...

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Veröffentlicht in:	Molecular vision 2009-01, Vol.15, p.76-88
Hauptverfasser:	Kirwan, Ruaidhrí P, Wordinger, Robert J, Clark, Abbot F, O'Brien, Colm J
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Line Down-Regulation Extracellular Matrix Proteins - genetics Extracellular Matrix Proteins - metabolism Fluorescent Antibody Technique Gene Expression Profiling Gene Expression Regulation Glaucoma, Open-Angle - genetics Glaucoma, Open-Angle - pathology Humans Oligonucleotide Array Sequence Analysis Optic Disk - metabolism Optic Disk - pathology Reproducibility of Results Reverse Transcriptase Polymerase Chain Reaction Transcription, Genetic Up-Regulation
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