human B cell methylome at 100-base pair resolution

Using a methylated-DNA enrichment technique (methylated CpG island recovery assay, MIRA) in combination with whole-genome tiling arrays, we have characterized by MIRA-chip the entire B cell "methylome" of an individual human at 100-bp resolution. We find that at the chromosome level high C...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2009-01, Vol.106 (3), p.671-678
Hauptverfasser:	Rauch, Tibor A, Wu, Xiwei, Zhong, Xueyan, Riggs, Arthur D, Pfeifer, Gerd P
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens, CD19 - genetics B lymphocytes B-Lymphocytes - metabolism Biological Sciences Cells Chromosome Mapping Chromosomes Correlations CpG Islands DNA DNA Methylation Gene expression Genes Genomes Genomics Humans Methylation Oligonucleotide Array Sequence Analysis Promoter regions Promoter Regions, Genetic Transcription initiation site
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