Involvement of the Acid Sphingomyelinase Pathway in UVA-induced Apoptosis

The sphingomyelin-ceramide pathway is an evolutionarily conserved ubiquitous signal transduction system that regulates many cell functions including apoptosis. Sphingomyelin (SM) is hydrolyzed to ceramide by different sphingomyelinases. Ceramide serves as a second messenger in mediating cellular eff...

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Veröffentlicht in:	The Journal of biological chemistry 2001-04, Vol.276 (15), p.11775-11782
Hauptverfasser:	Zhang, Yiguo, Mattjus, Peter, Schmid, Patricia C., Dong, Ziming, Zhong, Shuping, Ma, Wei-Ya, Brown, Rhoderick E., Bode, Ann M., Schmid, HaraldH.O., Dong, Zigang
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - radiation effects Cell Line, Transformed Enzyme Activation Enzyme Inhibitors - pharmacology Flavonoids - pharmacology Humans Imidazoles - pharmacology Mice Mice, Knockout Mitogen-Activated Protein Kinases - metabolism Phosphorylation Pyridines - pharmacology Sphingomyelin Phosphodiesterase - genetics Sphingomyelin Phosphodiesterase - metabolism Ultraviolet Rays
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