Collagen XVIII and corneal reinnervation following keratectomy
The significance of collagen XVIII in the regulation of corneal reinnervation remains largely unknown. We used whole-mount immunoconfocal microscopy to localize collagen XVIII to the nerve basement membrane of wild-type (WT) mouse corneas. Transmission electron microscopy showed corneal nerve disorg...
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| Veröffentlicht in: | FEBS letters 2008-10, Vol.582 (25), p.3674-3680 |
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| creator | Sakimoto, Tohru Kim, Tae-im Ellenberg, David Fukai, Naomi Jain, Sandeep Azar, Dimitri T. Chang, Jin-Hong |
| description | The significance of collagen XVIII in the regulation of corneal reinnervation remains largely unknown. We used whole-mount immunoconfocal microscopy to localize collagen XVIII to the nerve basement membrane of wild-type (WT) mouse corneas. Transmission electron microscopy showed corneal nerve disorganization in collagen XVIII knockout mice (col18a1
−/−). Antibody 2H3-specific neurofilament colocalized with collagens XVIII and IV and laminin-2 in WT mouse corneas, but did not colocalize with collagen IV and laminin-2 in col18a1
−/− mouse corneas. Following keratectomy, col18a1
−/− mice displayed decreased corneal neurite extension compared to WT mice. Our data indicate that collagen XVIII may play an important role in corneal reinnervation after wounding. |
| doi_str_mv | 10.1016/j.febslet.2008.09.052 |
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−/−). Antibody 2H3-specific neurofilament colocalized with collagens XVIII and IV and laminin-2 in WT mouse corneas, but did not colocalize with collagen IV and laminin-2 in col18a1
−/− mouse corneas. Following keratectomy, col18a1
−/− mice displayed decreased corneal neurite extension compared to WT mice. Our data indicate that collagen XVIII may play an important role in corneal reinnervation after wounding.</description><identifier>ISSN: 0014-5793</identifier><identifier>EISSN: 1873-3468</identifier><identifier>DOI: 10.1016/j.febslet.2008.09.052</identifier><identifier>PMID: 18840438</identifier><language>eng</language><publisher>England: Elsevier B.V</publisher><subject>Animals ; Collagen Type IV - genetics ; Collagen Type IV - physiology ; Collagen Type XVIII - genetics ; Collagen Type XVIII - physiology ; Collagen XVIII ; Cornea - innervation ; Cornea - physiology ; Corneal Injuries ; Extracellular matrix ; Mice ; Mice, Inbred C57BL ; Mice, Mutant Strains ; Microscopy, Electron, Transmission ; Nerve Regeneration - genetics ; Neurites - metabolism ; Neurites - physiology ; Peripheral Nerves - metabolism ; Peripheral Nerves - physiology ; Peripheral Nerves - ultrastructure ; Wound Healing - genetics</subject><ispartof>FEBS letters, 2008-10, Vol.582 (25), p.3674-3680</ispartof><rights>2008</rights><rights>FEBS Letters 582 (2008) 1873-3468 © 2015 Federation of European Biochemical Societies</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5920-15b3970f9e9ff0fce041137df94cb0ff0630c6c3331f30bed4ff40b5ff84b44a3</citedby><cites>FETCH-LOGICAL-c5920-15b3970f9e9ff0fce041137df94cb0ff0630c6c3331f30bed4ff40b5ff84b44a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1016%2Fj.febslet.2008.09.052$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.febslet.2008.09.052$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>230,314,780,784,885,1417,1433,3550,27924,27925,45574,45575,45995,46409,46833</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18840438$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sakimoto, Tohru</creatorcontrib><creatorcontrib>Kim, Tae-im</creatorcontrib><creatorcontrib>Ellenberg, David</creatorcontrib><creatorcontrib>Fukai, Naomi</creatorcontrib><creatorcontrib>Jain, Sandeep</creatorcontrib><creatorcontrib>Azar, Dimitri T.</creatorcontrib><creatorcontrib>Chang, Jin-Hong</creatorcontrib><title>Collagen XVIII and corneal reinnervation following keratectomy</title><title>FEBS letters</title><addtitle>FEBS Lett</addtitle><description>The significance of collagen XVIII in the regulation of corneal reinnervation remains largely unknown. We used whole-mount immunoconfocal microscopy to localize collagen XVIII to the nerve basement membrane of wild-type (WT) mouse corneas. Transmission electron microscopy showed corneal nerve disorganization in collagen XVIII knockout mice (col18a1
−/−). Antibody 2H3-specific neurofilament colocalized with collagens XVIII and IV and laminin-2 in WT mouse corneas, but did not colocalize with collagen IV and laminin-2 in col18a1
−/− mouse corneas. Following keratectomy, col18a1
−/− mice displayed decreased corneal neurite extension compared to WT mice. Our data indicate that collagen XVIII may play an important role in corneal reinnervation after wounding.</description><subject>Animals</subject><subject>Collagen Type IV - genetics</subject><subject>Collagen Type IV - physiology</subject><subject>Collagen Type XVIII - genetics</subject><subject>Collagen Type XVIII - physiology</subject><subject>Collagen XVIII</subject><subject>Cornea - innervation</subject><subject>Cornea - physiology</subject><subject>Corneal Injuries</subject><subject>Extracellular matrix</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Mice, Mutant Strains</subject><subject>Microscopy, Electron, Transmission</subject><subject>Nerve Regeneration - genetics</subject><subject>Neurites - metabolism</subject><subject>Neurites - physiology</subject><subject>Peripheral Nerves - metabolism</subject><subject>Peripheral Nerves - physiology</subject><subject>Peripheral Nerves - ultrastructure</subject><subject>Wound Healing - genetics</subject><issn>0014-5793</issn><issn>1873-3468</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkktvGyEUhVHVqnHc_oRWs-puJpeBebBJ1Vh5WIqURdqqO8QwFxd3DCmMHfnfh5GtPlaJWCDg3MO5-i4hHygUFGh9ti4MdnHAsSgB2gJEAVX5isxo27Cc8bp9TWYAlOdVI9gJOY1xDencUvGWnNC25cBZOyPnCz8MaoUu-_F9uVxmyvWZ9sGhGrKA1jkMOzVa7zKThP7RulX2C4MaUY9-s39H3hg1RHx_3Ofk29Xl18VNfnt3vVx8uc11JUrIadUx0YARKIwBoxE4pazpjeC6g3RVM9C1ZoxRw6DDnhvDoauMaXnHuWJzcn7wfdh2G-w1ujGoQT4Eu1FhL72y8v8XZ3_Kld_JsqZNk_6ak09Hg-B_bzGOcmOjxtS7Q7-NshZpNRV_VljSKSxlLxEmCs3kWB2EOvgYA5o_sSnIiaVcyyNLObGUIGRimeo-_tvz36ojvCS4OQge7YD7l7nKq8uL8n4ajGkuoAVohIBk9flghQnizmKQUVt0GnsbEmnZe_tM2iepKsk3</recordid><startdate>20081029</startdate><enddate>20081029</enddate><creator>Sakimoto, Tohru</creator><creator>Kim, Tae-im</creator><creator>Ellenberg, David</creator><creator>Fukai, Naomi</creator><creator>Jain, Sandeep</creator><creator>Azar, Dimitri T.</creator><creator>Chang, Jin-Hong</creator><general>Elsevier B.V</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20081029</creationdate><title>Collagen XVIII and corneal reinnervation following keratectomy</title><author>Sakimoto, Tohru ; Kim, Tae-im ; Ellenberg, David ; Fukai, Naomi ; Jain, Sandeep ; Azar, Dimitri T. ; Chang, Jin-Hong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5920-15b3970f9e9ff0fce041137df94cb0ff0630c6c3331f30bed4ff40b5ff84b44a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Animals</topic><topic>Collagen Type IV - genetics</topic><topic>Collagen Type IV - physiology</topic><topic>Collagen Type XVIII - genetics</topic><topic>Collagen Type XVIII - physiology</topic><topic>Collagen XVIII</topic><topic>Cornea - innervation</topic><topic>Cornea - physiology</topic><topic>Corneal Injuries</topic><topic>Extracellular matrix</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Mice, Mutant Strains</topic><topic>Microscopy, Electron, Transmission</topic><topic>Nerve Regeneration - genetics</topic><topic>Neurites - metabolism</topic><topic>Neurites - physiology</topic><topic>Peripheral Nerves - metabolism</topic><topic>Peripheral Nerves - physiology</topic><topic>Peripheral Nerves - ultrastructure</topic><topic>Wound Healing - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sakimoto, Tohru</creatorcontrib><creatorcontrib>Kim, Tae-im</creatorcontrib><creatorcontrib>Ellenberg, David</creatorcontrib><creatorcontrib>Fukai, Naomi</creatorcontrib><creatorcontrib>Jain, Sandeep</creatorcontrib><creatorcontrib>Azar, Dimitri T.</creatorcontrib><creatorcontrib>Chang, Jin-Hong</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>FEBS letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sakimoto, Tohru</au><au>Kim, Tae-im</au><au>Ellenberg, David</au><au>Fukai, Naomi</au><au>Jain, Sandeep</au><au>Azar, Dimitri T.</au><au>Chang, Jin-Hong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Collagen XVIII and corneal reinnervation following keratectomy</atitle><jtitle>FEBS letters</jtitle><addtitle>FEBS Lett</addtitle><date>2008-10-29</date><risdate>2008</risdate><volume>582</volume><issue>25</issue><spage>3674</spage><epage>3680</epage><pages>3674-3680</pages><issn>0014-5793</issn><eissn>1873-3468</eissn><abstract>The significance of collagen XVIII in the regulation of corneal reinnervation remains largely unknown. We used whole-mount immunoconfocal microscopy to localize collagen XVIII to the nerve basement membrane of wild-type (WT) mouse corneas. Transmission electron microscopy showed corneal nerve disorganization in collagen XVIII knockout mice (col18a1
−/−). Antibody 2H3-specific neurofilament colocalized with collagens XVIII and IV and laminin-2 in WT mouse corneas, but did not colocalize with collagen IV and laminin-2 in col18a1
−/− mouse corneas. Following keratectomy, col18a1
−/− mice displayed decreased corneal neurite extension compared to WT mice. Our data indicate that collagen XVIII may play an important role in corneal reinnervation after wounding.</abstract><cop>England</cop><pub>Elsevier B.V</pub><pmid>18840438</pmid><doi>10.1016/j.febslet.2008.09.052</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Collagen Type IV - genetics Collagen Type IV - physiology Collagen Type XVIII - genetics Collagen Type XVIII - physiology Collagen XVIII Cornea - innervation Cornea - physiology Corneal Injuries Extracellular matrix Mice Mice, Inbred C57BL Mice, Mutant Strains Microscopy, Electron, Transmission Nerve Regeneration - genetics Neurites - metabolism Neurites - physiology Peripheral Nerves - metabolism Peripheral Nerves - physiology Peripheral Nerves - ultrastructure Wound Healing - genetics |
| title | Collagen XVIII and corneal reinnervation following keratectomy |
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