PI3K Signaling in Glioma-Animal Models and Therapeutic Challenges

The PI3 kinase (PI3K) family plays a complex role in cell biology and metabolism. Signaling through the PI3Ks is frequently activated in many human cancers, including glioblastoma, because of gain‐of‐function mutations in PIK3CA or loss of PTEN. Experiments involving genetic mouse models and small m...

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Veröffentlicht in:	Brain pathology (Zurich, Switzerland) Switzerland), 2009-01, Vol.19 (1), p.112-120
Hauptverfasser:	Cheng, Christine K., Fan, Qi-Wen, Weiss, William A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Akt Animals apoptosis Class I Phosphatidylinositol 3-Kinases combination therapy Disease Models, Animal glioblastoma Glioblastoma - genetics Glioblastoma - metabolism Glioblastoma - therapy Glioma - genetics Glioma - metabolism Glioma - therapy Humans kinase inhibitors metabolism Mice MINI‐SYMPOSIUM: Mouse Models of Brain Tumors Phosphatidylinositol 3-Kinases - genetics Phosphatidylinositol 3-Kinases - metabolism PI3 kinase PTEN Phosphohydrolase - genetics PTEN Phosphohydrolase - metabolism Signal Transduction
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