Glucocorticoids induce transactivation of tight junction genes occludin and claudin-5 in retinal endothelial cells via a novel cis-element

Tight junctions between vascular endothelial cells help to create the blood–brain and blood–retinal barriers. Breakdown of the retinal tight junction complex is problematic in several disease states including diabetic retinopathy. Glucocorticoids can restore and/or preserve the endothelial barrier t...

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Veröffentlicht in:	Experimental eye research 2008-06, Vol.86 (6), p.867-878
Hauptverfasser:	Felinski, Edward A., Cox, Amy E., Phillips, Brett E., Antonetti, David A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Base Sequence Cattle Cells, Cultured claudin Claudin-5 Endothelial Cells - drug effects Endothelial Cells - metabolism Endothelium, Vascular - drug effects Endothelium, Vascular - metabolism Enhancer Elements, Genetic glucocorticoids Glucocorticoids - pharmacology Humans Membrane Proteins - genetics Membrane Proteins - metabolism Molecular Sequence Data Occludin Permeability Promoter Regions, Genetic Retinal Vessels - cytology Retinal Vessels - drug effects Retinal Vessels - metabolism tight junctions Tight Junctions - drug effects Tight Junctions - metabolism
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