High-Resolution Genomic Arrays Facilitate Detection of Novel Cryptic Chromosomal Lesions in Myelodysplastic Syndromes

Objective Unbalanced chromosomal aberrations are common in myelodysplastic syndromes and have prognostic implications. An increased frequency of cytogenetic changes may reflect an inherent chromosomal instability due to failure of DNA repair. Therefore, it is likely that chromosomal defects in myelo...

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Veröffentlicht in:	Experimental hematology 2007-02, Vol.35 (2), p.240-251
Hauptverfasser:	O'Keefe, Christine L, Tiu, Ramon, Gondek, Lukasz P, Powers, Jennifer, Theil, Karl S, Kalaycio, Matt, Lichtin, Alan, Sekeres, Mikkael A, Maciejewski, Jaroslaw P
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Advanced Basic Science Aged Cells, Cultured Chromosome Aberrations Cohort Studies Cytogenetic Analysis - methods Female Hematology, Oncology and Palliative Medicine Humans Karyotyping Male Middle Aged Minisatellite Repeats Myelodysplastic Syndromes - diagnosis Myelodysplastic Syndromes - genetics Nucleic Acid Hybridization - methods Oligonucleotide Array Sequence Analysis - methods Polymerase Chain Reaction - methods Polymorphism, Single Nucleotide Reproducibility of Results
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