Implementing an intervention to improve bone mineral density in survivors of childhood acute lymphoblastic leukemia: BONEII, a prospective placebo-controlled double-blind randomized interventional longitudinal study design

Abstract The BONEII study is a large two-phase study. The baseline study (Study 1) aims to estimate the prevalence of diminished bone mineral density (BMD) in patients treated for childhood acute lymphoblastic leukemia (ALL) and identify risk factors for BMD deficits. The interventional phase (Study...

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Veröffentlicht in:	Contemporary clinical trials 2008-09, Vol.29 (5), p.711-719
Hauptverfasser:	Rai, Shesh N, Hudson, Melissa M, McCammon, Elizabeth, Carbone, Laura, Tylavsky, Francis, Smith, Karen, Surprise, Harriet, Shelso, John, Pui, Chin-Hon, Kaste, Sue
Format:	Artikel
Sprache:	eng
Schlagworte:	Absorptiometry, Photon Acute lymphoblastic leukemia Biological and medical sciences Bone Density Bone loss Bone mineral density Calcium Cardiovascular Child Childhood cancer survivors Dietary Supplements Diseases of the osteoarticular system Double-Blind Method Female Hematologic and hematopoietic diseases Hematology, Oncology and Palliative Medicine Humans Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Longitudinal Studies Male Medical sciences Nutritional Status Osteoporosis - diagnosis Osteoporosis - etiology Osteoporosis - prevention & control Osteoporosis. Osteomalacia. Paget disease Pediatric leukemia Precursor Cell Lymphoblastic Leukemia-Lymphoma - complications Precursor Cell Lymphoblastic Leukemia-Lymphoma - mortality Precursor Cell Lymphoblastic Leukemia-Lymphoma - physiopathology Prospective Studies Repeated measures analysis Risk Factors Skeletal toxicities Survivors Vitamin D
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