Mouse early oocytes are transiently polar: Three-dimensional and ultrastructural analysis
The oocytes of many invertebrate and non-mammalian vertebrate species are not only asymmetrical but also polar in the distribution of organelles, localized RNAs and proteins, and the oocyte polarity dictates the patterning of the future embryo. Polarily located within the oocytes of many species is...
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| Veröffentlicht in: | Experimental cell research 2008-10, Vol.314 (17), p.3245-3254 |
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| creator | Kloc, Malgorzata Jaglarz, Mariusz Dougherty, Matthew Stewart, M. David Nel-Themaat, Liesl Bilinski, Szczepan |
| description | The oocytes of many invertebrate and non-mammalian vertebrate species are not only asymmetrical but also polar in the distribution of organelles, localized RNAs and proteins, and the oocyte polarity dictates the patterning of the future embryo. Polarily located within the oocytes of many species is the Balbiani body (Bb), which in
Xenopus is known to be associated with the germinal granules responsible for the determination of germ cell fate. In contrast, in mammals, it is widely believed that the patterning of the embryo does not occur before implantation, and that oocytes are non-polar and symmetrical. Although the oocytes of many mammals, including mice and humans, contain Bbs, it remains unknown how and if the presence of Bbs relates to mouse oocyte and egg polarity. Using three-dimensional reconstruction of mouse neonatal oocytes, we showed that mouse early oocytes are both asymmetrical and transiently polar. In addition, the specifics of polarity in mouse oocytes are highly reminiscent of those in
Xenopus early oocytes. Based on these findings, we conclude that the polarity of early oocytes imposed by the position of the centrioles at the cytoplasmic bridges is a fundamental and ancestral feature across the animal kingdom. |
| doi_str_mv | 10.1016/j.yexcr.2008.07.007 |
| format | Article |
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Xenopus is known to be associated with the germinal granules responsible for the determination of germ cell fate. In contrast, in mammals, it is widely believed that the patterning of the embryo does not occur before implantation, and that oocytes are non-polar and symmetrical. Although the oocytes of many mammals, including mice and humans, contain Bbs, it remains unknown how and if the presence of Bbs relates to mouse oocyte and egg polarity. Using three-dimensional reconstruction of mouse neonatal oocytes, we showed that mouse early oocytes are both asymmetrical and transiently polar. In addition, the specifics of polarity in mouse oocytes are highly reminiscent of those in
Xenopus early oocytes. Based on these findings, we conclude that the polarity of early oocytes imposed by the position of the centrioles at the cytoplasmic bridges is a fundamental and ancestral feature across the animal kingdom.</description><identifier>ISSN: 0014-4827</identifier><identifier>EISSN: 1090-2422</identifier><identifier>DOI: 10.1016/j.yexcr.2008.07.007</identifier><identifier>PMID: 18662685</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Animal reproduction ; Animals ; Balbiani body ; Cell Polarity ; Cellular biology ; Centriole ; Centrioles - ultrastructure ; Developmental biology ; Female ; Golgi ; Humans ; Immunohistochemistry ; Mice ; Models, Anatomic ; Mouse ; Oocyte ; Oocytes - ultrastructure ; Organelles - ultrastructure ; Ovary - cytology ; Polarity ; Ribonucleic acid ; RNA ; Rodents ; Xenopus ; Zona pellucida</subject><ispartof>Experimental cell research, 2008-10, Vol.314 (17), p.3245-3254</ispartof><rights>2008 Elsevier Inc.</rights><rights>Copyright © 2008 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c581t-8a519028b194cf2619bf6a06c725b431a0cc2d7fdb383cee03378da8f56a12023</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.yexcr.2008.07.007$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,780,784,885,3548,27922,27923,45993</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18662685$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kloc, Malgorzata</creatorcontrib><creatorcontrib>Jaglarz, Mariusz</creatorcontrib><creatorcontrib>Dougherty, Matthew</creatorcontrib><creatorcontrib>Stewart, M. David</creatorcontrib><creatorcontrib>Nel-Themaat, Liesl</creatorcontrib><creatorcontrib>Bilinski, Szczepan</creatorcontrib><title>Mouse early oocytes are transiently polar: Three-dimensional and ultrastructural analysis</title><title>Experimental cell research</title><addtitle>Exp Cell Res</addtitle><description>The oocytes of many invertebrate and non-mammalian vertebrate species are not only asymmetrical but also polar in the distribution of organelles, localized RNAs and proteins, and the oocyte polarity dictates the patterning of the future embryo. Polarily located within the oocytes of many species is the Balbiani body (Bb), which in
Xenopus is known to be associated with the germinal granules responsible for the determination of germ cell fate. In contrast, in mammals, it is widely believed that the patterning of the embryo does not occur before implantation, and that oocytes are non-polar and symmetrical. Although the oocytes of many mammals, including mice and humans, contain Bbs, it remains unknown how and if the presence of Bbs relates to mouse oocyte and egg polarity. Using three-dimensional reconstruction of mouse neonatal oocytes, we showed that mouse early oocytes are both asymmetrical and transiently polar. In addition, the specifics of polarity in mouse oocytes are highly reminiscent of those in
Xenopus early oocytes. Based on these findings, we conclude that the polarity of early oocytes imposed by the position of the centrioles at the cytoplasmic bridges is a fundamental and ancestral feature across the animal kingdom.</description><subject>Animal reproduction</subject><subject>Animals</subject><subject>Balbiani body</subject><subject>Cell Polarity</subject><subject>Cellular biology</subject><subject>Centriole</subject><subject>Centrioles - ultrastructure</subject><subject>Developmental biology</subject><subject>Female</subject><subject>Golgi</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Mice</subject><subject>Models, Anatomic</subject><subject>Mouse</subject><subject>Oocyte</subject><subject>Oocytes - ultrastructure</subject><subject>Organelles - ultrastructure</subject><subject>Ovary - cytology</subject><subject>Polarity</subject><subject>Ribonucleic acid</subject><subject>RNA</subject><subject>Rodents</subject><subject>Xenopus</subject><subject>Zona pellucida</subject><issn>0014-4827</issn><issn>1090-2422</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkcuO1DAQRS0EYpqBL0BCEQt2CWU7dhwkkNCIlzSIzbBgZTlOhXErHTd2MiJ_T_V0i9cCVpbKp6pu3cvYYw4VB66fb6sVv_tUCQBTQVMBNHfYhkMLpaiFuMs2ALwuayOaM_Yg5y0QaLi-z8640Vpoozbsy8e4ZCzQpXEtYvTrjLlwCYs5uSkHnGaq7-Po0ovi6johln3YIf3EyY2Fm_piGQnNc1r8vKTbmhvXHPJDdm9wY8ZHp_ecfX775urifXn56d2Hi9eXpVeGz6VxircgTMfb2g9C87YbtAPtG6G6WnIH3ou-GfpOGukRQcrG9M4MSjsuQMhz9uo4d790O-w9SSYZdp_CzqXVRhfsnz9TuLZf442lXRJA04BnpwEpflswz3YXssdxdBOSOVa3ulFSif-CpKaWtTpMfPoXuI1LIl-ypSvJd2VqguQR8inmnHD4KZmDPQRst_Y2YHsI2EJjKWDqevL7tb96TokS8PIIIHl-EzDZ7ClGj31I6Gfbx_DPBT8AiTi6Lg</recordid><startdate>20081015</startdate><enddate>20081015</enddate><creator>Kloc, Malgorzata</creator><creator>Jaglarz, Mariusz</creator><creator>Dougherty, Matthew</creator><creator>Stewart, M. David</creator><creator>Nel-Themaat, Liesl</creator><creator>Bilinski, Szczepan</creator><general>Elsevier Inc</general><general>Elsevier BV</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7TM</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20081015</creationdate><title>Mouse early oocytes are transiently polar: Three-dimensional and ultrastructural analysis</title><author>Kloc, Malgorzata ; Jaglarz, Mariusz ; Dougherty, Matthew ; Stewart, M. David ; Nel-Themaat, Liesl ; Bilinski, Szczepan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c581t-8a519028b194cf2619bf6a06c725b431a0cc2d7fdb383cee03378da8f56a12023</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Animal reproduction</topic><topic>Animals</topic><topic>Balbiani body</topic><topic>Cell Polarity</topic><topic>Cellular biology</topic><topic>Centriole</topic><topic>Centrioles - ultrastructure</topic><topic>Developmental biology</topic><topic>Female</topic><topic>Golgi</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Mice</topic><topic>Models, Anatomic</topic><topic>Mouse</topic><topic>Oocyte</topic><topic>Oocytes - ultrastructure</topic><topic>Organelles - ultrastructure</topic><topic>Ovary - cytology</topic><topic>Polarity</topic><topic>Ribonucleic acid</topic><topic>RNA</topic><topic>Rodents</topic><topic>Xenopus</topic><topic>Zona pellucida</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kloc, Malgorzata</creatorcontrib><creatorcontrib>Jaglarz, Mariusz</creatorcontrib><creatorcontrib>Dougherty, Matthew</creatorcontrib><creatorcontrib>Stewart, M. 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David</au><au>Nel-Themaat, Liesl</au><au>Bilinski, Szczepan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mouse early oocytes are transiently polar: Three-dimensional and ultrastructural analysis</atitle><jtitle>Experimental cell research</jtitle><addtitle>Exp Cell Res</addtitle><date>2008-10-15</date><risdate>2008</risdate><volume>314</volume><issue>17</issue><spage>3245</spage><epage>3254</epage><pages>3245-3254</pages><issn>0014-4827</issn><eissn>1090-2422</eissn><abstract>The oocytes of many invertebrate and non-mammalian vertebrate species are not only asymmetrical but also polar in the distribution of organelles, localized RNAs and proteins, and the oocyte polarity dictates the patterning of the future embryo. Polarily located within the oocytes of many species is the Balbiani body (Bb), which in
Xenopus is known to be associated with the germinal granules responsible for the determination of germ cell fate. In contrast, in mammals, it is widely believed that the patterning of the embryo does not occur before implantation, and that oocytes are non-polar and symmetrical. Although the oocytes of many mammals, including mice and humans, contain Bbs, it remains unknown how and if the presence of Bbs relates to mouse oocyte and egg polarity. Using three-dimensional reconstruction of mouse neonatal oocytes, we showed that mouse early oocytes are both asymmetrical and transiently polar. In addition, the specifics of polarity in mouse oocytes are highly reminiscent of those in
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| source | Elsevier ScienceDirect Journals Complete - AutoHoldings; MEDLINE |
| subjects | Animal reproduction Animals Balbiani body Cell Polarity Cellular biology Centriole Centrioles - ultrastructure Developmental biology Female Golgi Humans Immunohistochemistry Mice Models, Anatomic Mouse Oocyte Oocytes - ultrastructure Organelles - ultrastructure Ovary - cytology Polarity Ribonucleic acid RNA Rodents Xenopus Zona pellucida |
| title | Mouse early oocytes are transiently polar: Three-dimensional and ultrastructural analysis |
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