Most mammalian mRNAs are conserved targets of microRNAs

MicroRNAs (miRNAs) are small endogenous RNAs that pair to sites in mRNAs to direct post-transcriptional repression. Many sites that match the miRNA seed (nucleotides 2-7), particularly those in 3' untranslated regions (3'UTRs), are preferentially conserved. Here, we overhauled our tool for...

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Veröffentlicht in:	Genome Research 2009-01, Vol.19 (1), p.92-105
Hauptverfasser:	Friedman, Robin C, Farh, Kyle Kai-How, Burge, Christopher B, Bartel, David P
Format:	Artikel
Sprache:	eng
Schlagworte:	3' Untranslated Regions Animals Base Sequence Conserved Sequence Evolution, Molecular Humans Mammals - genetics Methods MicroRNAs - genetics Phylogeny RNA, Messenger - genetics Sequence Alignment Sequence Homology, Nucleic Acid
Online-Zugang:	Volltext
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