Myocardial infarction in sickle cell disease
Gross and microscopic findings consistent with acute (three patients) and healed (four patients) myocardial infarction were found in seven (9.7%) of 72 consecutive hearts from patients with sickle cell disease studied after autopsy between 1950 and 1982. Gross obstructive and atherosclerotic lesions...
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| Veröffentlicht in: | Journal of the National Medical Association 1996-07, Vol.88 (7), p.428-432 |
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| container_title | Journal of the National Medical Association |
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| creator | MARTIN, C. R JOHNSON, C. S COBB, C TATTER, D HAYWOOD, L. J |
| description | Gross and microscopic findings consistent with acute (three patients) and healed (four patients) myocardial infarction were found in seven (9.7%) of 72 consecutive hearts from patients with sickle cell disease studied after autopsy between 1950 and 1982. Gross obstructive and atherosclerotic lesions were absent in all seven patients, while microthrombi were present in the arterioles of infarcted tissue in two patients. Pathophysiological mechanisms responsible for the infarction are unclear, but anemia, platelet thrombi, coronary vasospasm, and abnormal rheology related to sickle cells may all be important. Chest pain occurred clinically in six of the seven patients and ECG findings typical of infarction were found in two patients. One patient died suddenly. These findings suggest that ischemic heart disease may be present in a significant number of patients with sickle cell disease and should be considered in all patients who complain of chest pain, whether or not the patient is in crisis. |
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R ; JOHNSON, C. S ; COBB, C ; TATTER, D ; HAYWOOD, L. J</creator><creatorcontrib>MARTIN, C. R ; JOHNSON, C. S ; COBB, C ; TATTER, D ; HAYWOOD, L. J</creatorcontrib><description>Gross and microscopic findings consistent with acute (three patients) and healed (four patients) myocardial infarction were found in seven (9.7%) of 72 consecutive hearts from patients with sickle cell disease studied after autopsy between 1950 and 1982. Gross obstructive and atherosclerotic lesions were absent in all seven patients, while microthrombi were present in the arterioles of infarcted tissue in two patients. Pathophysiological mechanisms responsible for the infarction are unclear, but anemia, platelet thrombi, coronary vasospasm, and abnormal rheology related to sickle cells may all be important. Chest pain occurred clinically in six of the seven patients and ECG findings typical of infarction were found in two patients. One patient died suddenly. These findings suggest that ischemic heart disease may be present in a significant number of patients with sickle cell disease and should be considered in all patients who complain of chest pain, whether or not the patient is in crisis.</description><identifier>ISSN: 0027-9684</identifier><identifier>EISSN: 1943-4693</identifier><identifier>PMID: 8764524</identifier><identifier>CODEN: JNMAAE</identifier><language>eng</language><publisher>Thorofare, NJ: Slack</publisher><subject>Adult ; Aged ; Anemia, Sickle Cell - complications ; Anemia, Sickle Cell - pathology ; Anemias. Hemoglobinopathies ; Autopsy ; Biological and medical sciences ; Diseases of red blood cells ; Female ; Hematologic and hematopoietic diseases ; Humans ; Male ; Medical sciences ; Middle Aged ; Myocardial Infarction - complications ; Myocardial Infarction - epidemiology ; Myocardial Infarction - pathology ; Prevalence ; Risk Factors</subject><ispartof>Journal of the National Medical Association, 1996-07, Vol.88 (7), p.428-432</ispartof><rights>1996 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2608008/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2608008/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,53791,53793</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3160883$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8764524$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>MARTIN, C. R</creatorcontrib><creatorcontrib>JOHNSON, C. S</creatorcontrib><creatorcontrib>COBB, C</creatorcontrib><creatorcontrib>TATTER, D</creatorcontrib><creatorcontrib>HAYWOOD, L. J</creatorcontrib><title>Myocardial infarction in sickle cell disease</title><title>Journal of the National Medical Association</title><addtitle>J Natl Med Assoc</addtitle><description>Gross and microscopic findings consistent with acute (three patients) and healed (four patients) myocardial infarction were found in seven (9.7%) of 72 consecutive hearts from patients with sickle cell disease studied after autopsy between 1950 and 1982. Gross obstructive and atherosclerotic lesions were absent in all seven patients, while microthrombi were present in the arterioles of infarcted tissue in two patients. Pathophysiological mechanisms responsible for the infarction are unclear, but anemia, platelet thrombi, coronary vasospasm, and abnormal rheology related to sickle cells may all be important. Chest pain occurred clinically in six of the seven patients and ECG findings typical of infarction were found in two patients. One patient died suddenly. These findings suggest that ischemic heart disease may be present in a significant number of patients with sickle cell disease and should be considered in all patients who complain of chest pain, whether or not the patient is in crisis.</description><subject>Adult</subject><subject>Aged</subject><subject>Anemia, Sickle Cell - complications</subject><subject>Anemia, Sickle Cell - pathology</subject><subject>Anemias. Hemoglobinopathies</subject><subject>Autopsy</subject><subject>Biological and medical sciences</subject><subject>Diseases of red blood cells</subject><subject>Female</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Myocardial Infarction - complications</subject><subject>Myocardial Infarction - epidemiology</subject><subject>Myocardial Infarction - pathology</subject><subject>Prevalence</subject><subject>Risk Factors</subject><issn>0027-9684</issn><issn>1943-4693</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkEtLxDAUhYMo4zj6E4QuxJWFvB8bQQZfoLjRdUhuU41m2jHpCPPvrVgGXd0L53A-ztlDc2I4q7k0bB_NMaaqNlLzQ3RUyjvGWBshZmimleSC8jm6eNz24HITXapi17oMQ-y78a1KhI8UKggpVU0swZVwjA5al0o4me4CvdxcPy_v6oen2_vl1UO9pgYPNaXCQ1BUAwiQhhspuAxeALQNAUOcVJ4bRb1nHnPtNeENA6q0wJQxTNgCXf7mrjd-FRoI3ZBdsuscVy5vbe-i_a908c2-9l-WSqzHjmPA-RSQ-89NKINdxfLTxHWh3xSrNCUKCzwaT_-Sdohpn1E_m3RXwKU2uw5i2dkYGYGasW9icG7J</recordid><startdate>19960701</startdate><enddate>19960701</enddate><creator>MARTIN, C. R</creator><creator>JOHNSON, C. S</creator><creator>COBB, C</creator><creator>TATTER, D</creator><creator>HAYWOOD, L. J</creator><general>Slack</general><general>National Medical Association</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19960701</creationdate><title>Myocardial infarction in sickle cell disease</title><author>MARTIN, C. R ; JOHNSON, C. S ; COBB, C ; TATTER, D ; HAYWOOD, L. J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p290t-225bce728cc5c69496546eb5ccfd1c91a67b4972bb3b048b814d3c27850233013</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Anemia, Sickle Cell - complications</topic><topic>Anemia, Sickle Cell - pathology</topic><topic>Anemias. Hemoglobinopathies</topic><topic>Autopsy</topic><topic>Biological and medical sciences</topic><topic>Diseases of red blood cells</topic><topic>Female</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Myocardial Infarction - complications</topic><topic>Myocardial Infarction - epidemiology</topic><topic>Myocardial Infarction - pathology</topic><topic>Prevalence</topic><topic>Risk Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>MARTIN, C. R</creatorcontrib><creatorcontrib>JOHNSON, C. S</creatorcontrib><creatorcontrib>COBB, C</creatorcontrib><creatorcontrib>TATTER, D</creatorcontrib><creatorcontrib>HAYWOOD, L. J</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of the National Medical Association</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>MARTIN, C. R</au><au>JOHNSON, C. S</au><au>COBB, C</au><au>TATTER, D</au><au>HAYWOOD, L. J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Myocardial infarction in sickle cell disease</atitle><jtitle>Journal of the National Medical Association</jtitle><addtitle>J Natl Med Assoc</addtitle><date>1996-07-01</date><risdate>1996</risdate><volume>88</volume><issue>7</issue><spage>428</spage><epage>432</epage><pages>428-432</pages><issn>0027-9684</issn><eissn>1943-4693</eissn><coden>JNMAAE</coden><abstract>Gross and microscopic findings consistent with acute (three patients) and healed (four patients) myocardial infarction were found in seven (9.7%) of 72 consecutive hearts from patients with sickle cell disease studied after autopsy between 1950 and 1982. Gross obstructive and atherosclerotic lesions were absent in all seven patients, while microthrombi were present in the arterioles of infarcted tissue in two patients. Pathophysiological mechanisms responsible for the infarction are unclear, but anemia, platelet thrombi, coronary vasospasm, and abnormal rheology related to sickle cells may all be important. Chest pain occurred clinically in six of the seven patients and ECG findings typical of infarction were found in two patients. One patient died suddenly. These findings suggest that ischemic heart disease may be present in a significant number of patients with sickle cell disease and should be considered in all patients who complain of chest pain, whether or not the patient is in crisis.</abstract><cop>Thorofare, NJ</cop><pub>Slack</pub><pmid>8764524</pmid><tpages>5</tpages></addata></record> |
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| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Adult Aged Anemia, Sickle Cell - complications Anemia, Sickle Cell - pathology Anemias. Hemoglobinopathies Autopsy Biological and medical sciences Diseases of red blood cells Female Hematologic and hematopoietic diseases Humans Male Medical sciences Middle Aged Myocardial Infarction - complications Myocardial Infarction - epidemiology Myocardial Infarction - pathology Prevalence Risk Factors |
| title | Myocardial infarction in sickle cell disease |
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