Reduction of prion infectivity in packed red blood cells

The link between a new variant form of Creutzfeldt–Jakob disease (vCJD) and the consumption of prion contaminated cattle meat as well as recent findings showing that vCJD can be transmitted by blood transfusion have raised public health concerns. Currently, a reliable test to identify prions in bloo...

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Veröffentlicht in:	Biochemical and biophysical research communications 2008-12, Vol.377 (2), p.373-378
Hauptverfasser:	Morales, Rodrigo, Buytaert-Hoefen, Kimberley A., Gonzalez-Romero, Dennisse, Castilla, Joaquin, Hansen, Eric T., Hlavinka, Dennis, Goodrich, Raymond P., Soto, Claudio
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES Animals BIOASSAY BLOOD CELLS Blood safety Blood Transfusion CATTLE Cell Separation - methods Creutzfeldt-Jakob Syndrome - prevention & control Cricetinae Diagnosis ENCEPHALITIS Erythrocytes - chemistry HAZARDS INFECTIVITY MEAT Prion diseases Prions PROTEINS PrPSc Proteins - isolation & purification PrPSc Proteins - pathogenicity PUBLIC HEALTH TRANSFUSIONS Transmissible spongiform encephalopathy
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