CD4 +CD25 + regulatory T cells are infected and activated during acute FIV infection

HIV-induced AIDS may be mediated by the activation of immunosuppressive CD4 +CD25 + T regulatory cells (Treg cells). Treg cells have been shown to regulate CD4 + and CD8 + immune responses to HIV and FIV antigens in vitro. We tested the hypothesis that Treg cells become infected and activated during...

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Veröffentlicht in:	Veterinary immunology and immunopathology 2008-12, Vol.126 (3), p.263-272
Hauptverfasser:	Mexas, Angela M., Fogle, Jonathan E., Tompkins, Wayne A., Tompkins, Mary B.
Format:	Artikel
Sprache:	eng
Schlagworte:	acute course Acute infection Animals biochemical mechanisms blood cell counts Cat Diseases - immunology Cats CD25-positive T-lymphocytes CD4-positive T-lymphocytes chronic diseases feline acquired immunodeficiency syndrome Feline Acquired Immunodeficiency Syndrome - immunology Feline immunodeficiency virus FIV Flow Cytometry - veterinary Forkhead Transcription Factors - metabolism Gene Expression Regulation - immunology HIV Immunodeficiency Virus, Feline - genetics Immunodeficiency Virus, Feline - immunology immunosuppression (physiological) infection interleukin-2 Interleukin-2 - immunology pathogenesis Regulatory T cells Reverse Transcriptase Polymerase Chain Reaction - veterinary T regulatory cells T-Lymphocytes, Regulatory - virology temporal variation viremia Viremia - veterinary
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