Integration of engrafted Schwann cells into injured peripheral nerve: Axonal association and nodal formation on regenerated axons

Transplantation of myelin-forming cells can remyelinate axons, but little is known of the sodium channel organization of axons myelinated by donor cells. Sciatic nerve axons of female wild type mice were transected by a crush injury and Schwann cells (SCs) from green fluorescence protein (GFP)-expre...

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Veröffentlicht in:	Neuroscience letters 2005-10, Vol.387 (2), p.85-89
Hauptverfasser:	Radtke, Christine, Akiyama, Yukinori, Lankford, Karen L., Vogt, Peter M., Krause, Diane S., Kocsis, Jeffery D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Axotomy Biological and medical sciences Cell Adhesion Molecules, Neuronal - metabolism Cell Compartmentation - physiology Cytoplasm - metabolism Cytoplasm - ultrastructure Disease Models, Animal Female Fundamental and applied biological sciences. Psychology Green Fluorescent Proteins - metabolism Immunohistochemistry Male Mice Mice, Inbred C57BL Microscopy, Electron, Transmission Myelin Sheath - physiology Myelin Sheath - ultrastructure NAV1.6 Voltage-Gated Sodium Channel Nerve Regeneration - physiology Nerve Tissue Proteins - metabolism Peripheral nerve Peripheral Nerve Injuries Peripheral Nerves - surgery Peripheral Nerves - ultrastructure Ranvier's Nodes - physiology Ranvier's Nodes - ultrastructure Schwann cells Schwann Cells - physiology Schwann Cells - transplantation Schwann Cells - ultrastructure Sciatic Neuropathy - metabolism Sciatic Neuropathy - physiopathology Sciatic Neuropathy - therapy Sodium Channels - metabolism Transplantation Vertebrates: nervous system and sense organs Y Chromosome - genetics Y Chromosome - metabolism
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