Paramyxoviruses: different receptors – different mechanisms of fusion
Paramyxovirus-mediated membrane fusion usually requires an interaction between the viral-attachment and -fusion proteins. The mechanism by which this interaction regulates fusion differs between paramyxoviruses that bind to sialic acid-containing receptors and those that recognize specific proteins....
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| Veröffentlicht in: | Trends in microbiology (Regular ed.) 2008-04, Vol.16 (4), p.135-137 |
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| container_title | Trends in microbiology (Regular ed.) |
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| creator | Iorio, Ronald M Mahon, Paul J |
| description | Paramyxovirus-mediated membrane fusion usually requires an interaction between the viral-attachment and -fusion proteins. The mechanism by which this interaction regulates fusion differs between paramyxoviruses that bind to sialic acid-containing receptors and those that recognize specific proteins. The recently solved structure of the globular head of the measles virus hemagglutinin suggests that this difference might be related to the location of the receptor-binding sites on the attachment proteins of the two classes of paramyxoviruses. |
| doi_str_mv | 10.1016/j.tim.2008.01.006 |
| format | Article |
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| identifier | ISSN: 0966-842X |
| ispartof | Trends in microbiology (Regular ed.), 2008-04, Vol.16 (4), p.135-137 |
| issn | 0966-842X 1878-4380 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Animals Binding Sites - genetics Hemagglutinins, Viral - chemistry Hemagglutinins, Viral - metabolism HN Protein - chemistry HN Protein - metabolism Humans Internal Medicine Measles virus Measles virus - metabolism Measles virus - pathogenicity Membrane Fusion Newcastle disease virus - metabolism Newcastle disease virus - pathogenicity Receptors, Virus - chemistry Receptors, Virus - metabolism Viral Proteins - chemistry Viral Proteins - metabolism |
| title | Paramyxoviruses: different receptors – different mechanisms of fusion |
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