Air pollution induces enhanced mitochondrial oxidative stress in cystic fibrosis airway epithelium

We studied the effects of airborne particulate matters (PM) on cystic fibrosis (CF) epithelium. We noted that PM enhanced human CF bronchial epithelial apoptosis, activated caspase-9 and PARP-1; and reduced mitochondrial membrane potential. Mitochondrial inhibitors (4,4-diisothiocyanatostilbene-2,2′...

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Veröffentlicht in:	FEBS letters 2008-10, Vol.582 (25), p.3601-3606
Hauptverfasser:	Kamdar, O., Le, Wei, Zhang, J., Ghio, A.J., Rosen, G.D., Upadhyay, D.
Format:	Artikel
Sprache:	eng
Schlagworte:	4,4′-diisothiocyanatostilbene-2,2′disulfonic acid AEC Air Pollution - adverse effects alveolar epithelial cells Ambient air pollution particle Apoptosis Apoptosis Regulatory Proteins - metabolism BAD Bcl2-antagonist of cell death Bronchi - drug effects Bronchi - metabolism Bronchi - pathology Cell Line CFTR Cystic fibrosis Cystic Fibrosis - pathology cystic fibrosis transmembrane conductance regulator DIDS Epithelium - drug effects Epithelium - pathology Humans Mitochondria Mitochondria - drug effects Mitochondria - metabolism NHBE normal human bronchial epithelial cells Oxidative Stress Particulate matter Particulate Matter - toxicity reactive oxygen species Respiratory Mucosa - drug effects Respiratory Mucosa - metabolism Respiratory Mucosa - pathology ROS thenoyltrifluoroacetone TTFA
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