Parkin Deficiency Increases Vulnerability to Inflammation-Related Nigral Degeneration

The loss of nigral dopaminergic (DA) neurons in idiopathic Parkinson's disease (PD) is believed to result from interactions between genetic susceptibility and environmental factors. Evidence that inflammatory processes modulate PD risk comes from prospective studies that suggest that higher pla...

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Veröffentlicht in:	The Journal of neuroscience 2008-10, Vol.28 (43), p.10825-10834
Hauptverfasser:	Frank-Cannon, Tamy C, Tran, Thi, Ruhn, Kelly A, Martinez, Terina N, Hong, John, Marvin, Marian, Hartley, Meagan, Trevino, Isaac, O'Brien, Daniel E, Casey, Bradford, Goldberg, Matthew S, Tansey, Malu G
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Behavior, Animal - drug effects Cell Survival - drug effects Cytokines - metabolism Dopamine - metabolism Exploratory Behavior - drug effects Exploratory Behavior - physiology Gait Disorders, Neurologic - etiology Gait Disorders, Neurologic - genetics Heme Oxygenase-1 - genetics Heme Oxygenase-1 - metabolism Inflammation - chemically induced Inflammation - complications Mice Mice, Knockout Motor Activity - drug effects Motor Activity - genetics Multivariate Analysis Nerve Degeneration - etiology Nerve Degeneration - metabolism NF-E2-Related Factor 2 - genetics NF-E2-Related Factor 2 - metabolism Nitric Oxide Synthase Type II - genetics Nitric Oxide Synthase Type II - metabolism Polysaccharides Psychomotor Performance - drug effects Psychomotor Performance - physiology Rotarod Performance Test Substantia Nigra - metabolism Substantia Nigra - pathology Superoxide Dismutase - genetics Superoxide Dismutase - metabolism Tyrosine 3-Monooxygenase Ubiquitin-Protein Ligases - deficiency
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