The SRA domain of UHRF1 flips 5-methylcytosine out of the DNA helix

Keeping DNA methylation on track DNA methylation is a key epigenetic process and the faithful maintenance of DNA methylation patterns is essential to the wellbeing of mammalian cells. This means that cells need a mechanism to identify the partially methylated version of CpG once a new DNA strand has...

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Veröffentlicht in:	Nature 2008-10, Vol.455 (7214), p.826-829
Hauptverfasser:	Hashimoto, Hideharu, Horton, John R., Zhang, Xing, Bostick, Magnolia, Jacobsen, Steven E., Cheng, Xiaodong
Format:	Artikel
Sprache:	eng
Schlagworte:	08 HYDROGEN 5-Methylcytosine - metabolism Animals Base Sequence Biological and medical sciences CpG Islands - genetics CRYSTAL STRUCTURE Crystalline structure Crystallography Crystallography, X-Ray Deoxyribonucleic acid DNA DNA - chemistry DNA - genetics DNA - metabolism DNA Methylation DNA REPLICATION Enzymes Fundamental and applied biological sciences. Psychology Humanities and Social Sciences HYDROGEN Hydrogen Bonding Hydrophobic and Hydrophilic Interactions letter MAINTENANCE METHYLATION Mice Models, Molecular Molecular biophysics Molecular Conformation multidisciplinary Nuclear Proteins - chemistry Nuclear Proteins - metabolism NUCLEOTIDES Phosphates Protein Binding Protein Structure, Tertiary PROTEINS Science Science (multidisciplinary) Structure in molecular biology SUBSTRATES
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