In vitro initial attachment of HIV-1 integrase to viral ends: control of the DNA specific interaction by the oligomerization state

HIV-1 integrase (IN) oligomerization and DNA recognition are crucial steps for the subsequent events of the integration reaction. Recent advances described the involvement of stable intermediary complexes including dimers and tetramers in the in vitro integration processes, but the initial attachmen...

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Veröffentlicht in:	Nucleic acids research 2008-12, Vol.36 (22), p.7043-7058
Hauptverfasser:	Lesbats, P, Métifiot, M, Calmels, C, Baranova, S, Nevinsky, G, Andreola, M.L, Parissi, V
Format:	Artikel
Sprache:	eng
Schlagworte:	Deoxyribonucleases Deoxyribonucleases - metabolism DNA, Viral DNA, Viral - metabolism HIV Integrase HIV Integrase - isolation & purification HIV Integrase - metabolism Human immunodeficiency virus 1 Life Sciences Microbiology and Parasitology Nucleic Acid Enzymes Oligodeoxyribonucleotides Oligodeoxyribonucleotides - chemistry Oligodeoxyribonucleotides - metabolism Protein Binding
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