Structure–activity relationships of bifunctional cyclic disulfide peptides based on overlapping pharmacophores at opioid and cholecystokinin receptors

Prolonged opioid exposure increases the expression of cholecystokinin (CCK) and its receptors in the central nervous system (CNS), where CCK may attenuate the antinociceptive effects of opioids. The complex interactions between opioid and CCK may play a role in the development of opioid tolerance. W...

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Veröffentlicht in:	Peptides (New York, N.Y. : 1980) N.Y. : 1980), 2008-08, Vol.29 (8), p.1413-1423
Hauptverfasser:	Agnes, Richard S., Ying, Jinfa, Kövér, Katalin E., Lee, Yeon Sun, Davis, Peg, Ma, Shou-wu, Badghisi, Hamid, Porreca, Frank, Lai, Josephine, Hruby, Victor J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Bifunctional peptides Biological and medical sciences Disulfides - chemical synthesis Disulfides - chemistry Drug Design Fundamental and applied biological sciences. Psychology G-Protein coupled receptors Models, Molecular Molecular Sequence Data Multivalent ligands Narcotic Antagonists NMR conformation Overlapping pharmacophores Pain Peptides, Cyclic - chemical synthesis Peptides, Cyclic - chemistry Receptors, Cholecystokinin - agonists Receptors, Cholecystokinin - antagonists & inhibitors Receptors, Opioid - agonists Structure-Activity Relationship Tolerance Vertebrates: endocrinology
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