Inhibitory effect of blocking TGF-beta/Smad signal on injury-induced fibrosis of corneal endothelium

To understand the role of TGF-beta related signals in the repair of a corneal endothelium defect and also to evaluate the therapeutic effect of Smad7 gene transfer on injury induced fibrosis of the corneal endothelium in rats. (1) Japanese albino rabbits (n=108) were used. Blocks of central cornea (...

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Veröffentlicht in:	Molecular vision 2008-12, Vol.14, p.2272-2281
Hauptverfasser:	Sumioka, Takayoshi, Ikeda, Kazuo, Okada, Yuka, Yamanaka, Osamu, Kitano, Ai, Saika, Shizuya
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviridae - genetics Animals Antibodies - pharmacology Burns - pathology Cell Movement - drug effects Cytokines - metabolism Disease Models, Animal Endothelium, Corneal - drug effects Endothelium, Corneal - pathology Endothelium, Corneal - ultrastructure Fibrosis Genetic Vectors - genetics Integrases - metabolism Mice Neutralization Tests Organ Culture Techniques Rabbits Rats Rats, Wistar Signal Transduction - drug effects Smad Proteins - antagonists & inhibitors Smad Proteins - metabolism Transduction, Genetic Transforming Growth Factor beta1 - antagonists & inhibitors Transforming Growth Factor beta1 - metabolism Transforming Growth Factor beta1 - pharmacology Transforming Growth Factor beta2 - pharmacology Wound Healing - drug effects
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