Spectral Monitoring of Surfactant Clearance during Alveolar Epithelial Type II Cell Differentiation

In this study, we report on the noninvasive identification of spectral markers of alveolar type II (ATII) cell differentiation in vitro using Raman microspectroscopy. ATII cells are progenitor cells for alveolar type I (ATI) cells in vivo, and spontaneously differentiate toward an ATI-like phenotype...

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Veröffentlicht in:	Biophysical journal 2008-12, Vol.95 (12), p.5978-5987
Hauptverfasser:	Swain, Robin J., Kemp, Sarah J., Goldstraw, Peter, Tetley, Teresa D., Stevens, Molly M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biomarkers - metabolism Cattle Cell Differentiation Cell Survival Cells Cellular Cellular biology Clearances Differentiation Discriminant analysis Epithelial Cells - cytology Epithelial Cells - metabolism Human Humans Lipids Markers Phenotype Principal Component Analysis Pulmonary Alveoli - cytology Pulmonary Surfactant-Associated Proteins - metabolism Spectra Spectroscopy, Imaging, Other Techniques Spectrum analysis Spectrum Analysis, Raman Surfactants Time Factors
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