Activation of the endocannabinoid system by organophosphorus nerve agents

Δ 9 -Tetrahydrocannabinol (THC), the psychoactive ingredient of marijuana, has useful medicinal properties but also undesirable side effects. The brain receptor for THC, CB 1 , is also activated by the endogenous cannabinoids anandamide and 2-arachidonylglycerol (2-AG). Augmentation of endocannabino...

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Veröffentlicht in:	Nature chemical biology 2008-06, Vol.4 (6), p.373-378
Hauptverfasser:	Blankman, Jacqueline L, Simon, Gabriel M, Nomura, Daniel K, Cravatt, Benjamin F, Fujioka, Kazutoshi, Issa, Roger S, Ward, Anna M, Casida, John E
Format:	Artikel
Sprache:	eng
Schlagworte:	Amidohydrolases - antagonists & inhibitors Animals Arachidonic Acid - analysis Arachidonic Acids - analysis Biochemical Engineering Biochemistry Bioorganic Chemistry Brain Brain - drug effects Brain - enzymology Brain - metabolism Cannabinoid Receptor Modulators - antagonists & inhibitors Cannabinoid Receptor Modulators - chemistry Cannabinoid Receptor Modulators - metabolism Cell Biology Chemistry Chemistry and Materials Science Chemistry/Food Science Endocannabinoids Fatty acids Female Glycerides - analysis Male Marijuana Mice Mice, Inbred C57BL Mice, Knockout Molecular Conformation Monoacylglycerol Lipases - antagonists & inhibitors Neurology Organophosphorus Compounds - chemistry Organophosphorus Compounds - pharmacology Pharmacology Polyunsaturated Alkamides - analysis Receptor, Cannabinoid, CB1 - agonists Receptor, Cannabinoid, CB1 - drug effects Receptors, Cannabinoid - drug effects Side effects Signal transduction Signal Transduction - drug effects Signal Transduction - physiology Stereoisomerism
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