5‐HT4‐elicited positive inotropic response is mediated by cAMP and regulated by PDE3 in failing rat and human cardiac ventricles

Background and purpose: The left ventricle in failing hearts becomes sensitive to 5‐HT parallelled by appearance of functional Gs‐coupled 5‐HT4 receptors. Here, we have explored the regulatory functions of phosphodiesterases in the 5‐HT4 receptor‐mediated functional effects in ventricular muscle fro...

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Veröffentlicht in:	British journal of pharmacology 2008-12, Vol.155 (7), p.1005-1014
Hauptverfasser:	Afzal, F, Andressen, K W, Mørk, H K, Aronsen, J M, Sjaastad, I, Dahl, C P, Skomedal, T, Levy, F O, Osnes, J‐B, Qvigstad, E
Format:	Artikel
Sprache:	eng
Schlagworte:	5‐HT 5‐HT4 receptor Animals Biological and medical sciences cAMP Cardiology. Vascular system Coronary Vessels - surgery Cyclic AMP - metabolism Cyclic Nucleotide Phosphodiesterases, Type 3 - metabolism Cyclic Nucleotide Phosphodiesterases, Type 4 - metabolism Heart heart failure Heart Failure - physiopathology Heart failure, cardiogenic pulmonary edema, cardiac enlargement Heart Ventricles - physiopathology Humans Ligation Male Medical sciences Middle Aged Myocardial Contraction - drug effects Myocardial Infarction - physiopathology Pharmacology. Drug treatments phosphodiesterase Phosphodiesterase 3 Inhibitors Phosphodiesterase 4 Inhibitors Radioimmunoassay Rats Rats, Wistar Receptors, Serotonin, 5-HT4 - metabolism Research Papers serotonin
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