Sequence variants in HTRA1 and LOC387715/ARMS2 and phenotype and response to photodynamic therapy in neovascular age-related macular degeneration in populations from Israel

Single nucleotide polymorphisms (SNPs) in the tightly linked LOC387715/ARMS2 and HTRA1 genes have been associated with age-related macular degeneration (AMD). We tested whether these SNPs are associated with AMD in Israeli populations, if they underlie variable phenotype and response to therapy in n...

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Veröffentlicht in:	Molecular vision 2008-12, Vol.14, p.2263-2271
Hauptverfasser:	Chowers, Itay, Meir, Tal, Lederman, Michal, Goldenberg-Cohen, Nitza, Cohen, Yoram, Banin, Eyal, Averbukh, Edward, Hemo, Itzhak, Pollack, Ayala, Axer-Siegel, Ruth, Weinstein, Orly, Hoh, Josephine, Zack, Donald J, Galbinur, Tural
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Alleles Asian People - genetics Case-Control Studies Demography Female Gene Expression Regulation Gene Frequency Genotype High-Temperature Requirement A Serine Peptidase 1 Humans Israel Leukocytes - metabolism Macular Degeneration - drug therapy Macular Degeneration - genetics Male Neovascularization, Pathologic - genetics Phenotype Photochemotherapy Polymorphism, Single Nucleotide - genetics Proteins - genetics RNA, Messenger - genetics RNA, Messenger - metabolism Serine Endopeptidases - blood Serine Endopeptidases - genetics
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