SREBP Activity Is Regulated by mTORC1 and Contributes to Akt-Dependent Cell Growth

Cell growth (accumulation of mass) needs to be coordinated with metabolic processes that are required for the synthesis of macromolecules. The PI3-kinase/Akt signaling pathway induces cell growth via activation of complex 1 of the target of rapamycin (TORC1). Here we show that Akt-dependent lipogene...

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Veröffentlicht in:Cell metabolism 2008-09, Vol.8 (3), p.224-236
Hauptverfasser: Porstmann, Thomas, Santos, Claudio R., Griffiths, Beatrice, Cully, Megan, Wu, Mary, Leevers, Sally, Griffiths, John R., Chung, Yuen-Li, Schulze, Almut
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Sprache:eng
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