Notch signaling regulates growth and differentiation in the mammalian lens

The Notch signal transduction pathway regulates the decision to proliferate versus differentiate. Although there are a myriad of mouse models for the Notch pathway, surprisingly little is known about how these genes regulate early eye development, particularly in the anterior lens. We employed both...

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Veröffentlicht in:	Developmental biology 2008-09, Vol.321 (1), p.111-122
Hauptverfasser:	Rowan, Sheldon, Conley, Kevin W., Le, Tien T., Donner, Amy L., Maas, Richard L., Brown, Nadean L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Activated Notch Animals Cell Differentiation Cell Proliferation CKI Cyclin D1 - metabolism Cyclin D2 Cyclin-Dependent Kinase Inhibitor p27 - metabolism Cyclins Cyclins - metabolism Embryo, Mammalian - metabolism Growth Immunoglobulin J Recombination Signal Sequence-Binding Protein - metabolism Lens development Lens, Crystalline - cytology Lens, Crystalline - embryology Mice Notch signaling Rbpj Receptor, Notch1 - metabolism
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