Isoform-selective histone deacetylase inhibitors

Histone deacetylase (HDAC) proteins are transcription regulators linked to cancer. As a result, multiple small molecule HDAC inhibitors are in various phases of clinical trials as anti-cancer drugs. The majority of HDAC inhibitors non-selectively influence the activities of eleven human HDAC isoform...

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Veröffentlicht in:	Chemical Society reviews 2008-01, Vol.37 (7), p.1402-1413
Hauptverfasser:	Bieliauskas, Anton V, Pflum, Mary Kay H
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Binding Sites Cell Proliferation - drug effects Drug Design Enzyme Inhibitors - chemistry Enzyme Inhibitors - pharmacology Histone Deacetylase Inhibitors Histone Deacetylases - chemistry Humans Hydroxamic Acids - pharmacology Protein Isoforms - antagonists & inhibitors Protein Isoforms - chemistry Tumor Cells, Cultured
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