The Hsk1(Cdc7) replication kinase regulates origin efficiency

Origins of DNA replication are generally inefficient, with most firing in fewer than half of cell cycles. However, neither the mechanism nor the importance of the regulation of origin efficiency is clear. In fission yeast, origin firing is stochastic, leading us to hypothesize that origin inefficien...

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Veröffentlicht in:	Molecular biology of the cell 2008-12, Vol.19 (12), p.5550-5558
Hauptverfasser:	Patel, Prasanta K, Kommajosyula, Naveen, Rosebrock, Adam, Bensimon, Aaron, Leatherwood, Janet, Bechhoefer, John, Rhind, Nicholas
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Cycle Proteins - genetics Cell Cycle Proteins - metabolism Cell Nucleus - metabolism Chromosomal Instability DNA Replication Fluorescence Recovery After Photobleaching Gene Expression Regulation, Fungal Plasmids - genetics Plasmids - metabolism Protein Kinases - genetics Protein Kinases - metabolism Protein Serine-Threonine Kinases - genetics Protein Serine-Threonine Kinases - metabolism Replication Origin Schizosaccharomyces - cytology Schizosaccharomyces - physiology Schizosaccharomyces pombe Proteins - genetics Schizosaccharomyces pombe Proteins - metabolism
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