Global DNA Hypomethylation Is Associated with High Serum-Persistent Organic Pollutants in Greenlandic Inuit

Background: Persistent organic pollutants (POPs) may influence epigenetic mechanisms; therefore, they could affect chromosomal stability and gene expression. DNA methylation, an epigenetic mechanism, has been associated with cancer initiation and progression. Greenlandic Inuit have some of the highe...

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Veröffentlicht in:	Environmental health perspectives 2008-11, Vol.116 (11), p.1547-1552
Hauptverfasser:	Rusiecki, Jennifer A., Baccarelli, Andrea, Bollati, Valentina, Tarantini, Letizia, Moore, Lee E., Bonefeld-Jorgensen, Eva C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Age Aged Assaying Assessments Battery Beta Blood Blood plasma Cancer Cigarette smoking Correlation analysis Deoxyribonucleic acid DNA DNA - drug effects DNA Methylation Environmental health Environmental Pollutants - toxicity Epigenetics Estimates Ethylene Ethylene vinyl acetates Female Gene expression Genetic aspects Greenland Health Health aspects Humans Inuits Inverse Linear regression Male Methylation Middle Aged Organic Chemicals - analysis Organic Chemicals - toxicity Persistent organic pollutants Pesticides - toxicity Pollutants Polymerase chain reaction Regression Risk factors Samples Statistical analysis Statistical methods
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