Conformational transition of Sec machinery inferred from bacterial SecYE structures

Over 30% of proteins are secreted across or integrated into membranes. Their newly synthesized forms contain either cleavable signal sequences or non-cleavable membrane anchor sequences, which direct them to the evolutionarily conserved Sec translocon (SecYEG in prokaryotes and Sec61, comprising -,...

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Veröffentlicht in:	Nature (London) 2008-10, Vol.455 (7215), p.988-991
Hauptverfasser:	Perederina, Anna, Tsukazaki, Tomoya, Ishitani, Ryuichiro, Ito, Koreaki, Mori, Takaharu, Vassylyev, Dmitry G, Mori, Hiroyuki, Fukai, Shuya, Nureki, Osamu, Dohmae, Naoshi, Sugita, Yuji
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacteria Bacterial proteins Bacterial Proteins - chemistry Bacterial Proteins - genetics Bacterial Proteins - immunology Bacterial Proteins - metabolism Bacteriology Binding Sites Biological and medical sciences Crystallography, X-Ray Disulfides - chemistry Disulfides - metabolism E coli Fundamental and applied biological sciences. Psychology Genetic aspects Humanities and Social Sciences Hydrophobic and Hydrophilic Interactions Immunoglobulin Fab Fragments - chemistry Immunoglobulin Fab Fragments - immunology letter Methanococcus - chemistry Methanococcus - enzymology Microbiology Models, Biological Models, Molecular Monoclonal antibodies multidisciplinary Permeability, membrane transport, intracellular transport Protein Binding Protein Structure, Tertiary Proteins Science Science (multidisciplinary) Thermus thermophilus - chemistry Thermus thermophilus - enzymology Thermus thermophilus - genetics Translocation Translocation (Genetics)
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