Immunologic mechanisms suggested in the association of M. pneumoniae infection and extrapulmonary disease: a review

Numerous case reports and retrospective studies suggest an association between M. pneumoniae respiratory infection and extrapulmonary complications, the most common of which involve the central nervous system. There is insufficient evidence based on prospective, carefully controlled observations to...

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Veröffentlicht in:	The Yale journal of biology & medicine 1983, Vol.56 (5-6), p.475-479
1. Verfasser:	Fernald, G W
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Bacterial - analysis Autoantibodies - analysis Autoimmune Diseases - immunology Bacterial Toxins Brain - immunology Central Nervous System Diseases - epidemiology Central Nervous System Diseases - etiology Central Nervous System Diseases - immunology Humans Immune Tolerance Mycoplasma pneumoniae Mycoplasma pneumoniae - immunology Pneumonia, Mycoplasma - complications Pneumonia, Mycoplasma - epidemiology Pneumonia, Mycoplasma - immunology
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container_title	The Yale journal of biology & medicine
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creator	Fernald, G W
description	Numerous case reports and retrospective studies suggest an association between M. pneumoniae respiratory infection and extrapulmonary complications, the most common of which involve the central nervous system. There is insufficient evidence based on prospective, carefully controlled observations to confirm this association at the present time. A variety of mechanisms has been suggested to explain the involvement of distant organ systems. These include metastatic infection, autoimmunity, toxin generation, and altered host immunity. While none of these is based on evidence to prove an association, the state of anergy which accompanies M. pneumoniae pneumonia deserves consideration and further study as the most plausible link between infecting organisms and extrapulmonary manifestations.
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There is insufficient evidence based on prospective, carefully controlled observations to confirm this association at the present time. A variety of mechanisms has been suggested to explain the involvement of distant organ systems. These include metastatic infection, autoimmunity, toxin generation, and altered host immunity. 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subjects	Animals Antibodies, Bacterial - analysis Autoantibodies - analysis Autoimmune Diseases - immunology Bacterial Toxins Brain - immunology Central Nervous System Diseases - epidemiology Central Nervous System Diseases - etiology Central Nervous System Diseases - immunology Humans Immune Tolerance Mycoplasma pneumoniae Mycoplasma pneumoniae - immunology Pneumonia, Mycoplasma - complications Pneumonia, Mycoplasma - epidemiology Pneumonia, Mycoplasma - immunology
title	Immunologic mechanisms suggested in the association of M. pneumoniae infection and extrapulmonary disease: a review
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