The Rapid Decrease in Astrocyte-Associated Dystroglycan Expression by Focal Cerebral Ischemia is Protease-Dependent

During focal cerebral ischemia, the detachment of astrocytes from the microvascular basal lamina is not completely explained by known integrin receptor expression changes. Here, the impact of experimental ischemia (oxygen—glucose deprivation (OGD)) on dystroglycan expression by murine endothelial ce...

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Veröffentlicht in:	Journal of cerebral blood flow and metabolism 2008-04, Vol.28 (4), p.812-823
Hauptverfasser:	Milner, Richard, Hung, Stephanie, Wang, Xiaoyun, Spatz, Maria, del Zoppo, Gregory J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Astrocytes Astrocytes - metabolism Basal lamina Biological and medical sciences Blotting, Western Brain - blood supply Brain - metabolism Brain Ischemia - metabolism Cell Adhesion - physiology Cells, Cultured Cerebral blood flow Collagen Cortex Dystroglycan Dystroglycans - biosynthesis Endothelial cells Endothelial Cells - metabolism Flow Cytometry Gene Expression Glucose Immunohistochemistry Injuries Integrin alpha6beta4 - biosynthesis Integrins Internet Ischemia Laminin Male Medical sciences Metabolism Mice Microvasculature Neostriatum Neurology Neuropharmacology Neuroprotective agent Oxygen Papio Peptide Hydrolases - metabolism perlecan Pharmacology. Drug treatments Primates Reverse Transcriptase Polymerase Chain Reaction Substantia alba Vascular diseases and vascular malformations of the nervous system
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