Aptamers that recognize drug-resistant HIV-1 reverse transcriptase

Drug-resistant variants of HIV-1 reverse transcriptase (RT) are also known to be resistant to anti-RT RNA aptamers. In order to be able to develop diagnostics and therapies that can focus on otherwise drug-resistant viruses, we have isolated two aptamers against a well-known, drug-resistant HIV-1 RT...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Nucleic acids research 2008-12, Vol.36 (21), p.6739-6751
Hauptverfasser:	Li, Na, Wang, Yuxuan, Pothukuchy, Arti, Syrett, Angel, Husain, Naeem, Gopalakrisha, Siddharth, Kosaraju, Pradeepa, Ellington, Andrew D
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-HIV Agents - therapeutic use Aptamers, Nucleotide - chemistry Base Sequence Drug Resistance, Viral - genetics HIV Reverse Transcriptase - analysis HIV Reverse Transcriptase - chemistry HIV Reverse Transcriptase - genetics HIV-1 - drug effects HIV-1 - genetics Human immunodeficiency virus 1 Molecular Sequence Data Mutation Nucleic Acid Conformation Protein Array Analysis RNA
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!