A Novel Adenovirus Expressing Flt3 Ligand Enhances Mucosal Immunity by Inducing Mature Nasopharyngeal-Associated Lymphoreticular Tissue Dendritic Cell Migration

Previously, we showed that nasal administration of a naked cDNA plasmid expressing Flt3 ligand (FL) cDNA (pFL) enhanced CD4(+) Th2-type, cytokine-mediated mucosal immunity and increased lymphoid-type dendritic cell (DC) numbers. In this study, we investigated whether targeting nasopharyngeal-associa...

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Veröffentlicht in:	The Journal of immunology (1950) 2008-06, Vol.180 (12), p.8126-8134
Hauptverfasser:	Sekine, Shinichi, Kataoka, Kosuke, Fukuyama, Yoshiko, Adachi, Yasuo, Davydova, Julia, Yamamoto, Masato, Kobayashi, Ryoki, Fujihashi, Keiko, Suzuki, Hideaki, Curiel, David T, Shizukuishi, Satoshi, McGhee, Jerry R, Fujihashi, Kohtaro
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviridae - genetics Adenovirus Adjuvants, Immunologic - genetics Administration, Intranasal Animals Cell Differentiation - genetics Cell Differentiation - immunology Cell Line Cell Line, Tumor Cell Movement - genetics Cell Movement - immunology Dendritic Cells - cytology Dendritic Cells - immunology Dendritic Cells - metabolism Dendritic Cells - virology Female fms-Like Tyrosine Kinase 3 - metabolism Genetic Vectors - administration & dosage Humans Immunity, Mucosal - genetics Lymphoid Tissue - cytology Lymphoid Tissue - immunology Lymphoid Tissue - virology Membrane Proteins - administration & dosage Membrane Proteins - biosynthesis Membrane Proteins - genetics Mice Mice, Inbred C57BL Mononuclear Phagocyte System - cytology Mononuclear Phagocyte System - immunology Mononuclear Phagocyte System - virology Nasopharynx - cytology Nasopharynx - immunology Nasopharynx - virology
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