Isolation and expression analysis of foxj1 and foxj1.2 in zebrafish embryos
In this report, we present the isolation and identification of a zebrafish homolog of the winged helix\forkhead transcription factor Foxj1. Foxj1 was identified in other species but not in zebrafish. Foxj1 was shown in mice to be required in ciliogenesis and left-right asymmetry establishment. Here...
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Veröffentlicht in: | The International journal of developmental biology 2008, Vol.52 (7), p.985-991 |
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description | In this report, we present the isolation and identification of a zebrafish homolog of the winged helix\forkhead transcription factor Foxj1. Foxj1 was identified in other species but not in zebrafish. Foxj1 was shown in mice to be required in ciliogenesis and left-right asymmetry establishment. Here we present a spatio-temporal expression pattern of zebrafish foxj1, showing that this gene is expressed in dorsal forerunner cells, Kupffers vesicle, the floor plate, pronephric ducts and kidney. This expression pattern is overlapping but different from that of the foxj1.2, the closest related gene in zebrafish. Foxj1 in zebrafish appears to have similar functions as those reported in other species connected to ciliogenesis and left-right asymmetry. |
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subjects | Amino Acid Sequence Animals Cilia - metabolism Danio rerio Embryo, Nonmammalian Forkhead Transcription Factors - genetics Forkhead Transcription Factors - metabolism Freshwater Gene Expression In Situ Hybridization Left-Right Determination Factors Molecular Sequence Data Phylogeny Sequence Homology, Amino Acid Zebrafish - embryology Zebrafish - genetics Zebrafish - metabolism Zebrafish Proteins - genetics Zebrafish Proteins - metabolism |
title | Isolation and expression analysis of foxj1 and foxj1.2 in zebrafish embryos |
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