Isolation and expression analysis of foxj1 and foxj1.2 in zebrafish embryos

In this report, we present the isolation and identification of a zebrafish homolog of the winged helix\forkhead transcription factor Foxj1. Foxj1 was identified in other species but not in zebrafish. Foxj1 was shown in mice to be required in ciliogenesis and left-right asymmetry establishment. Here...

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Veröffentlicht in:The International journal of developmental biology 2008, Vol.52 (7), p.985-991
Hauptverfasser: Aamar, Emil, Dawid, Igor B
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Dawid, Igor B
description In this report, we present the isolation and identification of a zebrafish homolog of the winged helix\forkhead transcription factor Foxj1. Foxj1 was identified in other species but not in zebrafish. Foxj1 was shown in mice to be required in ciliogenesis and left-right asymmetry establishment. Here we present a spatio-temporal expression pattern of zebrafish foxj1, showing that this gene is expressed in dorsal forerunner cells, Kupffers vesicle, the floor plate, pronephric ducts and kidney. This expression pattern is overlapping but different from that of the foxj1.2, the closest related gene in zebrafish. Foxj1 in zebrafish appears to have similar functions as those reported in other species connected to ciliogenesis and left-right asymmetry.
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source MEDLINE; Alma/SFX Local Collection
subjects Amino Acid Sequence
Animals
Cilia - metabolism
Danio rerio
Embryo, Nonmammalian
Forkhead Transcription Factors - genetics
Forkhead Transcription Factors - metabolism
Freshwater
Gene Expression
In Situ Hybridization
Left-Right Determination Factors
Molecular Sequence Data
Phylogeny
Sequence Homology, Amino Acid
Zebrafish - embryology
Zebrafish - genetics
Zebrafish - metabolism
Zebrafish Proteins - genetics
Zebrafish Proteins - metabolism
title Isolation and expression analysis of foxj1 and foxj1.2 in zebrafish embryos
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